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The human microbiome, global health and the Sustainable Development Goals: opportunities and challenges

The human microbiome has a crucial role in global health, with implications for achieving the Sustainable Development Goals (SDGs). Understanding and harnessing the potential of the microbiome, while recognizing its link to the global ecosystem, can drive innovative strategies for improved public health, and promote sustainable development.

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References

  1. Shanahan, F., Ghosh, T. S. & O’Toole, P. W. The healthy microbiome — what is the definition of a healthy gut microbiome? Gastroenterology 160, 483–494 (2021).

    Article  PubMed  Google Scholar 

  2. Shanahan, F., Ghosh, T. S. & O’Toole, P. W. Human microbiome variance is underestimated. Curr. Opin. Microbiol. 73, 102288 (2023).

    Article  PubMed  Google Scholar 

  3. Chen, R. Y. et al. A microbiota-directed food intervention for undernourished children. N. Engl. J. Med. 384, 1517–1528 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gacesa, R. et al. Environmental factors shaping the gut microbiome in a Dutch population. Nature 604, 732–739 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Ayeni, K. I., Berry, D., Wisgrill, L., Warth, B. & Ezekiel, C. N. Early-life chemical exposome and gut microbiome development: African research perspectives within a global environmental health context. Trends Microbiol. 30, 1084–1100 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. Amato, K. R. et al. The human gut microbiome and health inequities. Proc. Natl Acad. Sci. USA 118, e2017947118 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cavicchioli, R. et al. Scientists’ warning to humanity: microorganisms and climate change. Nat. Rev. Microbiol. 17, 569–586 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Shanahan, F., Ghosh, T. S., Molloy, M. G. & O’Toole, P. W. The nonindustrialised microbiome in a modern world. Clin. Sci. (Lond.) 136, 1683–1690 (2022).

    Article  PubMed  Google Scholar 

  9. Keohane, D. M. et al. Microbiome and health implications for ethnic minorities after enforced lifestyle changes. Nat. Med. 26, 1089–1095 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. O’Toole, P. W. & Paoli, M. The contribution of microbial biotechnology to sustainable development goals: microbiome therapies. Microb. Biotechnol. 10, 1066–1069 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Work in P.W.O.T.’s laboratory is supported in part by awards from Science Foundation Ireland to APC Microbiome Ireland; the Department of Agriculture, Food & Marine (Government of Ireland) FIRM programme; the European Union’s Horizons programme (MASTER-818368); and its Research and innovation programme (IHMCSA; 964590). P.W.O.T. is a research proposal reviewer/advisor for The Weston Family Foundation, and the US Highbush Blueberry Council. Work by M.P. at UNESCO-TWAS is supported by the Italian Government, the Swedish International Development and Cooperation Agency, the German Federal Ministry for Education and Research and the Elsevier Foundation. The ideas and opinions expressed in this article are those of the authors and do not necessarily represent the view of UNESCO.

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Correspondence to Paul W. O’Toole.

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Related links

Horizon Europe project MASTER: https://www.master-h2020.eu/

Human Microbiome Action: https://humanmicrobiomeaction.eu/

Human Microbiome Project: https://hmpdacc.org/

International Human Microbiome Consortium: https://ihmc2024rome.com/

Microbiome Support Consortium: https://www.microbiomesupport.eu/

One Health fact sheet: https://www.who.int/news-room/fact-sheets/detail/one-health

UNESCO-TWAS: https://twas.org/

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O’Toole, P.W., Paoli, M. The human microbiome, global health and the Sustainable Development Goals: opportunities and challenges. Nat Rev Microbiol 21, 624–625 (2023). https://doi.org/10.1038/s41579-023-00924-z

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