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In this Review, Howden and co-workers examine and integrate recent key advances in understanding the mechanisms that Staphylococcus aureus uses to cause infections.
Yang et al. present the fluorogenic reversible reporter SURF to monitor real-time interactions between the SARS-CoV-2 spike protein and ACE2, and identify compounds that block such interaction.
In this Review, the authors summarize the mutations harboured by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. They describe the impact of mutations on virus infectivity and transmissibility, and discuss SARS-CoV-2 evolution in the context of T cells, innate immunity and population immunity.
This study reports that Acinetobacter baumannii establishes intracellular reservoirs in the bladder that can seed recurrent infections following catheterization.
A recent study found that the Helicobacter pylori genome evolves during disease progression and that these genomic changes select for effective colonizers of gastric metaplasia.
A recent study reports the development of a biomarker-responsive engineered bacterium that can diagnose, record and treat inflammatory bowel disease in mice.
Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore our knowledge of long COVID and highlight key findings, including potential mechanisms, the overlap with other conditions and potential treatments. They also discuss challenges and recommendations for long COVID research and care.
Xie et al. show that the harmaline metabolite produced by Akkermansia muciniphila modulates nuclear factor-κB signalling and reduces severe fever with thrombocytopenia syndrome severity.
In this Review, Minkoff and tenOever examine the relationship between SARS-CoV-2 biology and innate immunity, and they explore how antagonism and dysregulation of host innate immune defences contribute to COVID-19 disease severity.
This Genome Watch explores how metagenomics aids in profiling plant-derived microorganisms and molecules that could have an impact on the composition and function of the human gut microbiome.
Thaiss and colleagues report a gut–brain connection in mice that regulates the motivation for exercise, linking the intestinal microbiome to midbrain dopamine signalling.
In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to counter colonization resistance.
Although numerous tick-borne viruses are seemingly apathogenic in humans, a number of emerging tick-borne viruses have been recently identified to possess human-infection potential, with more yet to be discovered. Here, we call for greater research efforts to better delineate their precise disease burden and threats posed to global public health.
Arevalo et al. have developed a nucleoside-modified mRNA-lipid nanoparticle vaccine encoding separate haemagglutinin antigens from all known influenza virus subtypes.
Meyer et al. show that Toxoplasma gondii infection influences wolf behaviour in the wild, increasing risk-taking behaviours such as dispersing from a pack and becoming a pack leader.
