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This study reports a bacterial antiphage protein that contains a NACHT domain, which is also found in metazoan proteins that mediate immunity and inflammation.
In this Review, Wang, Gao and Aksoy delve into the influence of microbiota on vector physiology and competence, provide an overview of the common and unique characteristics of microbiota in major disease vector systems and examine the potential applications of manipulating vector microbiota for vector control purposes.
This study reports the identification of an inhibitor of a Toxoplasma gondii myosin motor protein that could be exploited to prevent or treat infections with T. gondii and other apicomplexan parasites.
In this Review, Martínez, Hernando-Amado and colleagues explore how eco-evolutionary-based approaches can aid in the design of successful antibiotic therapies, including the exploitation of evolutionary trade-offs, targeting bacterial metabolism and studying the ancestral functions of antibiotic resistance determinants.
In this study, Brown et al. show that nutrient deprivation increases Plasmodium falciparum survival and tolerance to the antimalarial drug artemisinin.
Shigella spp. that are resistant to almost all antimicrobial classes are increasing in prevalence and becoming globally dominant. The situation is critical and highlights a trend that is mirrored by other enteric bacterial pathogens. New interventions to prevent and treat these infections are essential to tackle a potential public health catastrophe.
In this study, Carfrae et al. show that inhibition of biotin and fatty acid synthesis restores colistin activity against Gram-negative bacteria and prevents colistin resistance.
In this Review, Carmody and Bisanz examine the role of the gut microbiome in energy metabolism, the two-way relationship between the gut microbiome and weight management strategies and opportunities and challenges in the development of microbiome-directed therapies targeting energy balance.
This Genome Watch highlights how combining next-generation sequencing and imaging technologies sheds light on the diverse and intricate symbiotic relationships of uncultivated archaea and bacteria.
In this Review, Singh et al. explore the impact of future climate scenarios on plant pathogen burden and biogeography, their interaction with the plant microbiome and the consequences on plant disease and productivity in different ecosystems. They propose different approaches to ensure long-term global food security.
In this Review, Lemon and colleagues describe quasi-enveloped virions, how they enter and how they are released from the human host cell, and how they affect host immunity and pathogenesis.
In this Review, Smith, Foster and colleagues explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. They discuss new therapies for treating disease and how to minimize resistance evolution.
Over the course of the lifespan of a host, the gut microbiota undergoes evolutionary changes and is shaped by ecological interactions with the host and other microbial species. In this Review, Barreto and Gordo explore mechanisms of evolution of the gut microbiota, intrahost evolution of strains and communities and implications of intrahost evolution for disease and microbiota-based therapies.
A recent study reports that uropathogenic Escherichia coli infection triggers trained immunity in urinary tract tissue, which affects the immune response to subsequent infections.
This study investigated the environmental microbiomes of cities by sampling urban beehives, providing insight into the surrounding metagenomic landscape that is relevant to beehive and human health.
