Volume 17 Issue 4, April 2016

Volume 17 Issue 4

'Circles' by Vicky Summersby, inspired by the Progress article on p205.

Research Highlights



  • Review Article |

    As most mitochondrial proteins are encoded in the nucleus, mitochondrial activity requires efficient communication between the nuclear and mitochondrial genomes. This is mediated by nucleus-to-mitochondria (anterograde), mitochondria-to-nucleus (retrograde) and mitonuclear feedback signalling, as well as the integrated stress response and extracellular communication, which regulate homeostasis and, consequently, healthspan and lifespan.

    • Pedro M. Quirós
    • , Adrienne Mottis
    •  & Johan Auwerx
  • Review Article |

    The versatile RNA-degradation functions of the RNA exosome complex make it crucial for RNA biogenesis. It is now emerging that the nuclear exosome is a specific regulator of gene expression in different physiological processes, and that it has a role in transcription regulation and in maintaining genome stability.

    • Cornelia Kilchert
    • , Sina Wittmann
    •  & Lidia Vasiljeva
  • Review Article |

    Ephrin ligands and Eph receptor Tyr kinases are transmembrane proteins that elicit short-distance cell–cell signalling when they interact. As both Eph kinases and ephrins exist in various isoforms and function as receptors or ligands, this signalling evokes versatile responses, which regulate a plethora of morphogenetic and homeostatic processes.

    • Artur Kania
    •  & Rüdiger Klein



  • Opinion |

    Quante and Bird propose that the epigenome is modulated by the recruitment of cell type-specific DNA-binding proteins to short, abundant sequence motifs. The regulation of gene expression may thus be simplified by tuning gene expression in multigene blocks.

    • Timo Quante
    •  & Adrian Bird