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Volume 17 Issue 3, March 2016

'Fates and translational potential of pluripotent stem cells' by Vicky Summersby, inspired by this Focus issue.

Volume 17 Issue 3

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Research Highlight

  • A study now reveals that adult hair follicle stem cells are established through asymmetric cell divisions and asymmetric signalling, in the absence of a stem cell niche.

    • Paulina Strzyz
    Research Highlight

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In Brief

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Research Highlight

  • Sumoylation of MCM inhibits DNA replication initiation by counteracting the function of the kinases that activate MCM; the loss of MCM sumoylation coincides with origin firing.

    • Kim Baumann
    Research Highlight

  • The removal of senescent cells from middle-aged mice can extend healthspan by attenuating age-related organ dysfunction.

    • Kirsty Minton
    Research Highlight
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In Brief

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Journal Club

  • Azim Surani discusses how induced pluripotent stem cells have enabled researchers to demonstrate that it is possible to cross the germ line–soma barrier, known as the Weismann barrier.

    • M. Azim Surani
    Journal Club
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Research Highlight

  • A new method to validate the translation of upstream open reading frames reveals their function during the integrated stress response.

    • Eytan Zlotorynski
    Research Highlight
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Foreword

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Review Article

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Timeline

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Science and Society

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