Volume 16 Issue 10, October 2015

Volume 16 Issue 10

'A slice of epigenetics' by Vicky Summersby, inspired by the Review on p593 and the 15th anniversary of Nature Reviews Molecular Cell Biology.

Research Highlights

Progress

  • Progress |

    Pseudouridine is the most abundant internal post-transcriptional modification of spliceosomal small nuclear RNAs and ribosomal RNAs. Transcriptome-wide maps of RNA pseudouridylation have recently established that pseudouridines are also found in mRNAs, potentially representing a new mechanism of proteomic diversification.

    • John Karijolich
    • , Chengqi Yi
    •  & Yi-Tao Yu

    Collection:

  • Progress |

    Recent findings revealed the extent to which mitochondrial translation and other cellular processes are mutually controlled. Mitochondrial translation is coordinated with the assembly of respiratory chain complexes and is positively regulated by microRNAs imported from the cytoplasm. In turn, mitochondrial translation stress activates retrograde signalling pathways that suppress cell proliferation.

    • Ricarda Richter-Dennerlein
    • , Sven Dennerlein
    •  & Peter Rehling

Reviews

  • Review Article |

    The chromatin-based epigenetic changes that occur during ageing and the role of chromatin modifiers in lifespan have recently been highlighted. The importance of epigenome remodelling by environmental stimuli for transcriptional and genomic stability is emerging, and such remodelling could provide new targets to counter ageing or age-related diseases.

    • Bérénice A. Benayoun
    • , Elizabeth A. Pollina
    •  & Anne Brunet
  • Review Article |

    Centrosomes are important microtubule organizers. As many proteins are concentrated at centrosomes, including cell cycle and signalling regulators, centrosomes are also likely to coordinate important cell decisions. Recent findings have shed light on the functions of centrosomes in animal cells and on the mechanisms of centrosome assembly and maturation during mitosis.

    • Paul T. Conduit
    • , Alan Wainman
    •  & Jordan W. Raff
  • Review Article |

    At each ovulation cycle, the single-layer epithelia that encapsulate mammalian ovaries undergo rupture and rapid repair. Recent studies have identified stem cell pools that ensure ovarian epithelial homeostasis, thus providing insights into the regulation of stem cell function and the contribution of stem cells to ovarian tumorigenesis.

    • Annie Ng
    •  & Nick Barker