Abstract
Pseudouridylation is the most abundant internal post-transcriptional modification of stable RNAs, with fundamental roles in the biogenesis and function of spliceosomal small nuclear RNAs (snRNAs) and ribosomal RNAs (rRNAs). Recently, the first transcriptome-wide maps of RNA pseudouridylation were published, greatly expanding the catalogue of known pseudouridylated RNAs. These data have further implicated RNA pseudouridylation in the cellular stress response and, moreover, have established that mRNAs are also targets of pseudouridine synthases, potentially representing a novel mechanism for expanding the complexity of the cellular proteome.
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Acknowledgements
The authors would like to thank members of the Yu laboratory for insightful discussions.
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Karijolich, J., Yi, C. & Yu, YT. Transcriptome-wide dynamics of RNA pseudouridylation. Nat Rev Mol Cell Biol 16, 581–585 (2015). https://doi.org/10.1038/nrm4040
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DOI: https://doi.org/10.1038/nrm4040
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