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This Viewpoint discusses the role of stool DNA testing as a new diagnostic tool for detecting colorectal cancer. Preliminary data show it to have better performance characteristics than fecal occult blood testing, however, in its current form sensitivity remains low. Stool DNA testing needs to be studied in larger cohorts of asymptomatic patients, and new markers need to be developed before its role in colorectal cancer screening can be fully established.
This Review considers the bacterial virulence factors and host inflammatory responses involved in the development of gastric cancer afterHelicobacter pylori infection, as well as the signaling pathways affected and possible molecular targets for intervention. The effect of H. pylori eradication and the modification of environmental conditions on the progression of the gastric carcinogenic process triggered by H. pyloriare also discussed.
Advances in our understanding of the molecular events underlying the activation of the immune system have led to the development of a new generation of small molecules with immunosuppressive properties and that serve as immunomodulators. In this Review, the authors report on the progress that has been made in the development of small molecules in the field of gastroenterology.
