Volume 15 Issue 5, May 2018

Alcohol use and 'social' drinking are increasing among the young and particularly in women. However, gender equity does not extend to the risk of alcohol-associated liver disease and alcoholic hepatitis, which are increased and often caused by as little as half as much cumulative alcohol consumption in women compared with men.

The stomach responds to injury via two main patterns, the superficial response and the glandular response. In this Review, Sáenz and Mills discuss cellular plasticity and reprogramming in the stomach in the context of disease (such as gastric cancer) and during repair and homeostasis.

Elastography is the most accurate noninvasive approach to assess liver fibrosis in patients with NAFLD. Here, the authors discuss the benefits and limitations of various elastographic modalities, their role in the optimal management of NAFLD and directions for future research.

A growing body of evidence suggests that chronic hepatitis C infection is associated with an increased rate of extrahepatic cancers. In this Review, the authors summarize epidemiological studies exploring this relationship and provide insights into the potential mechanisms underlying a causal link.

Gastrointestinal motor disorders affect a large proportion of the population worldwide. In this Consensus Statement, the authors describe recommended tests for the investigation of gastric, small bowel and colonic motility, with an emphasis on how best to classify gastrointestinal motor disorders to guide treatment decisions.

Faecal incontinence and evacuation disorders are common and substantially impair quality of life. In this Consensus Statement, the authors describe recommended tests for the evaluation of anorectal function and the clinical relevance of these tests in the management of patients to help guide the practising clinician.