“The daisies of the gut” — human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” — human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” – human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” — human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” — human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” – human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

“The daisies of the gut” — human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

"The daisies of the gut" — Cover image supplied by Maxime M. Mahe and Holly M. Poling, Department of Pediatric Surgery at Cincinnati Children's Hospital Medical Center, USA. Human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

"The daisies of the gut" — Cover image supplied by Maxime M. Mahe and Holly M. Poling, Department of Pediatric Surgery at Cincinnati Children's Hospital Medical Center, USA. Human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

"The daisies of the gut" — Cover image supplied by Maxime M. Mahe and Holly M. Poling, Department of Pediatric Surgery at Cincinnati Children's Hospital Medical Center, USA. Human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

"The daisies of the gut" — Cover image supplied by Maxime M. Mahe and Holly M. Poling, Department of Pediatric Surgery at Cincinnati Children's Hospital Medical Center, USA. Human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.

"The daisies of the gut" — Cover image supplied by Maxime M. Mahe and Holly M. Poling, Department of Pediatric Surgery at Cincinnati Children's Hospital Medical Center, USA. Human intestinal organoids (HIOs) were generated from pluripotent stem cells through a directed differentiation process in vitro. The HIOs were then transplanted under the kidney capsule of immunocompromised mice, where they developed into complex intestinal tissue resembling the human intestine. The image depicts an epithelial cross-section of a transplanted HIO. Epithelial cells form saccular structures at the base of the epithelium called crypts, which are surrounded by endothelial vessels.