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Funcke et al. shed light on the management of leptin replacement therapy in monogenic obesity by identifying two LEP variants with antagonistic functional effects. Their groundbreaking study emphasizes the urgent need for in-depth understanding of the genetic factors involved in obesity to pave the way for tailored interventions.
This Review discusses the physiological and neurological mechanisms that drive altered eating behaviours in pregnancy, including food cravings, food aversions and changes in sensory perception, and the implications for the long-term health of the gestational parent and offspring.
This Review discusses challenges in the management of Cushing disease in adults and provides information to help with planning an integrated and individualized approach for each patient.
Endocrine-disrupting chemicals (EDCs) contribute to human disease, disability and economic damage. This Review outlines a set of evidence-based policy actions to manage, minimize or eliminate the use of EDCs, alongside a number of specific challenges and potential recommendations.
