Volume 15 Issue 8, August 2019

Exercise is the elixir of health. However, timing can boost or blunt exercise performance and health benefits. Two complementary studies used transcriptomic and metabolomic tools to dissect how time of day affects the impact of exercise. The findings open new avenues for optimizing timing of physical activity to boost its benefits further.

Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.

The blood–brain barrier (BBB), which is widely known as the border that separates circulating blood from the brain, is also a secretory body. This Review examines the various ways in which the BBB exhibits endocrine-related properties.

Obesity among children and adolescents is highly prevalent in both developed and developing countries. This Review discusses data on the early determinants of childhood obesity in order to provide relevant strategies for daily clinical work.

This Review discusses the two main functions of the human deiodinases: the homeostatic control of plasma concentrations of thyroid hormone and the control of intracellular T₃ concentrations.

Mammalian sperm RNA carries hereditary information that regulates offspring metabolic health. This Perspectives discusses how the RNA code in sperm might be decoded in the early embryo and transformed molecular signals to influence embryonic development and offspring phenotypes.