The December issue includes Reviews on hepatic fatty acid synthesis and partitioning, bile acids in glucose metabolism and insulin signalling, the effects of space travel on reproduction and the role of circulating microRNAs in obesity.

Our November issue features Reviews on the pathogenesis of type 1 diabetes mellitus, the role of osteoblasts in energy homeostasis and the underlying mechanisms and treatment of endometriosis.

This issue includes Reviews on the glucoregulatory mechanisms of metformin, circadian clocks and thyroid function and the mechanisms and management of Turner syndrome, as well as a Perspectives on the care of people with differences of sex development.

This issue includes Reviews on the endocrine function of adipose tissue, the human stress response, fracture prediction in osteoporosis and the pathophysiology of adrenocortical carcinoma.

Our August issue features articles on the blood–brain barrier, childhood obesity, thyroid hormone homeostasis and the role of sperm RNA in offspring metabolic health.

Our July issue includes articles on exercise and muscle–brain crosstalk, the circadian regulation of food intake, pregnancy outcomes in women with diabetes mellitus, adrenal function and dysfunction in critically ill patients and vascular complications in young people with type 1 diabetes mellitus.

Our June issue includes articles on combating obesity with exercise, prolactin, thyroid hormonogenesis and endocrine disruptors.

Our May issue includes articles on gut microbial metabolites, mechanisms of weight regain after weight loss, overgrowth syndromes and the epidemiology and pathogenesis of obesity.

Our April issue includes articles on circadian rhythms and exercise, innervation of adipose tissue, enteroendocrine cells and gut hormones and the function of motilin.

Our March issue includes articles on the obese adipose microenvironment, modelling the endocrine pancreas and post-transplant diabetes mellitus.

Our February issue includes articles on circadian clocks and insulin resistance, combination pharmacotherapies for metabolic diseases and the role of melatonin in type 2 diabetes mellitus and obesity. This issue also features four Year in Review articles covering advances in endocrinology from the past year.

Our January issue features articles on cancer cachexia, hypoxia-inducible factors in metabolic disease, the calcium-sensing receptor and the biology of PCSK9 beyond LDL control.

Fluorescence image of peri-islet vasodilation and lymphocytic infiltration in experimental type 1 diabetes mellitus. This non-obese diabetic mouse islet is under autoimmune attack. Lymphocytes are packed inside the lymphatic vessels and are infiltrating toward the islet. The infiltration and inflammation process is featured with the blood and lymphatic vasodilation.