Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Uusitupa, M. et al. Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention study—secondary analysis of the randomized trial. PLOS ONE 4, e5656 (2009).
Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes study. Lancet Diabetes Endocrinol. 3, 866–875 (2015).
Gong, Q. et al. Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia 54, 300–307 (2011).
Li, G. et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention study: a 20-year follow-up Study. Lancet 371, 1783–1789 (2008).
Li, G. et al. Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study. Lancet Diabetes Endocrinol. 2, 474–480 (2014).
Gong, Q. et al. Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study. Lancet Diabetes Endocrinol. 7, 452–461 (2019).
UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317, 703–713 (1998).
McAuley, P. A. et al. Fitness, fatness, and survival in adults with prediabetes. Diabetes Care 37, 529–536 (2014).
Johnson, J. L. et al. Ten-year legacy effects of three eight-month exercise training programs on cardiometabolic health parameters. Front. Physiol. 10, 452 (2019).
Echouffo-Tcheugui, J. B. & Dagogo-Jack, S. Preventing diabetes mellitus in developing countries. Nat. Rev. Endocrinol. 8, 557–562 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
S.D.J. is a principal investigator in the multicentre Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study.
Rights and permissions
About this article
Cite this article
Dagogo-Jack, S. Prevention begets prevention — lessons from the Da Qing Study. Nat Rev Endocrinol 15, 442–443 (2019). https://doi.org/10.1038/s41574-019-0227-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41574-019-0227-1