Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 5 Issue 12, December 2010

Measuring the physical properties of the bases in DNA molecules as they pass through a nanopore could form the basis of a new approach for sequencing DNA. Theorists have predicted that the quantum tunnelling of electrons can be used to identify bases, and experimenters have confirmed that tunnelling can be used to sense individual bases attached to a sugar (or a sugar and one or more phosphate groups). Now Stuart Lindsay and co-workers have shown that tunnelling from the tip of a scanning tunnelling microscope to a gold surface can be used to distinguish between different bases in the region between them. Combining such a recognition junction with a method for pulling DNA molecules through a nanopore in a controlled manner would allow researchers to read tens of bases per second. This illustration shows a single adenine base being read as it is bound by recognition molecules on the tip and surface to complete a chemical tunnelling circuit.

Image credit: Hao Liu

Letter p868; News & Views p828

Editorial

Top of page ⤴

Correspondence

Top of page ⤴

Research Highlights

Top of page ⤴

News & Views

  • Can silicon ever be a true direct-bandgap semiconductor? The first observation of a new, short-lived photoluminescence band from silicon nanocrystals offers fresh hope.

    • Dmitry Kovalev
    News & Views
  • A pump–probe approach allows the relaxation times of single spins to be measured.

    • Alexander Ako Khajetoorians
    • André Kubetzka
    News & Views
  • Ionic-conductance measurements show that proton mobility in 2-nm-deep hydrophilic channels is up to four times as high as bulk values of mobility.

    • Hirofumi Daiguji
    News & Views
Top of page ⤴

Correction

Top of page ⤴

Review Article

  • RNA can be designed and manipulated to form well-defined structures with useful functions. This article reviews the synthesis of RNA nanoparticles, the applications of such nanoparticles in nanomedicine, and future challenges for the field of RNA nanotechnology.

    • Peixuan Guo
    Review Article
Top of page ⤴

Letter

Top of page ⤴

Article

Top of page ⤴

Corrigendum

Top of page ⤴

Erratum

Top of page ⤴
Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research

Search

Quick links