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Measuring the physical properties of the bases in DNA molecules as they pass through a nanopore could form the basis of a new approach for sequencing DNA. Theorists have predicted that the quantum tunnelling of electrons can be used to identify bases, and experimenters have confirmed that tunnelling can be used to sense individual bases attached to a sugar (or a sugar and one or more phosphate groups). Now Stuart Lindsay and co-workers have shown that tunnelling from the tip of a scanning tunnelling microscope to a gold surface can be used to distinguish between different bases in the region between them. Combining such a recognition junction with a method for pulling DNA molecules through a nanopore in a controlled manner would allow researchers to read tens of bases per second. This illustration shows a single adenine base being read as it is bound by recognition molecules on the tip and surface to complete a chemical tunnelling circuit.
Can silicon ever be a true direct-bandgap semiconductor? The first observation of a new, short-lived photoluminescence band from silicon nanocrystals offers fresh hope.
RNA can be designed and manipulated to form well-defined structures with useful functions. This article reviews the synthesis of RNA nanoparticles, the applications of such nanoparticles in nanomedicine, and future challenges for the field of RNA nanotechnology.
Aberration-corrected scanning transmission electron microscopy, combined with dynamical multislice image simulations, can identify individual atoms in supported rhodium–iridium clusters and map their full structure.
Nanochannels fabricated by standard semiconductor techniques can exhibit enhanced cation mobilities that are up to four times as high as bulk values of the mobility.
Thin films made of silver flakes and multiwalled carbon nanotubes decorated with silver nanoparticles are highly conductive and are capable of being stretched and printed.
Carbon-nanotube transistors exhibit improved performance when their channel length is scaled from 3 μm to 15 nm, and are adversely affected by contact length scaling below 100 nm.
A single α-haemolysin protein is inserted into a solid-state nanopore to form a hybrid structure that is potentially more suited towards creating wafer-scale device arrays for genomic sequencing and protein studies.
An ultrafast visible band in the photoluminescence spectrum of silicon nanocrystals increases in intensity and shifts to longer wavelengths as the size of the nanocrystals decreases.