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Volume 5 Issue 12, December 2010

Measuring the physical properties of the bases in DNA molecules as they pass through a nanopore could form the basis of a new approach for sequencing DNA. Theorists have predicted that the quantum tunnelling of electrons can be used to identify bases, and experimenters have confirmed that tunnelling can be used to sense individual bases attached to a sugar (or a sugar and one or more phosphate groups). Now Stuart Lindsay and co-workers have shown that tunnelling from the tip of a scanning tunnelling microscope to a gold surface can be used to distinguish between different bases in the region between them. Combining such a recognition junction with a method for pulling DNA molecules through a nanopore in a controlled manner would allow researchers to read tens of bases per second. This illustration shows a single adenine base being read as it is bound by recognition molecules on the tip and surface to complete a chemical tunnelling circuit.

Image credit: Hao Liu

Letter p868; News & Views p828

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News & Views

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    • Dmitry Kovalev
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  • A pump–probe approach allows the relaxation times of single spins to be measured.

    • Alexander Ako Khajetoorians
    • André Kubetzka
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  • Ionic-conductance measurements show that proton mobility in 2-nm-deep hydrophilic channels is up to four times as high as bulk values of mobility.

    • Hirofumi Daiguji
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Correction

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Review Article

  • RNA can be designed and manipulated to form well-defined structures with useful functions. This article reviews the synthesis of RNA nanoparticles, the applications of such nanoparticles in nanomedicine, and future challenges for the field of RNA nanotechnology.

    • Peixuan Guo
    Review Article
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