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Volume 16 Issue 7, July 2021

Volume 16 Issue 7

A conformable mesh for the treatment of glioblastoma

A biodegradable implant — the μMESH, comprising an ordered array of micrometric polymeric strands deposited over a water-soluble microlayer — represents a powerful device to deploy complex combination therapies for the eradication of brain cancer and other malignancies. The compartmentalized μMESH can be efficiently loaded with small molecules, biologicals and nanomedicines. In the treatment of glioblastoma, the μMESH conforms to the surface of the resected cavity, establishes a localized high-concentration drug depot, and deploys deep into the malignant tissue a variety of therapeutic agents that would not spontaneously cross the blood/brain barrier. The μMESH micrometric architecture and mechanical flexibility facilitate its fine entanglement with the malignant mass, and dictate tumour eradication. The cover presents a μMESH in the act of wrapping around a glioblastoma tumour spheroid, demonstrating the ability to establish intimate interactions with the malignant tissue. The image was acquired by confocal microscopy with a 10× objective and results from the maximum intensity projection of multiple z-sections over a 200-μm-thick sample. In the tumour spheroid, U87-MG cells appear green (GFP+ cells) with blue nuclei (DAPI staining). The μMESH is loaded with Rhodamine B molecules returning polymeric strands with a red colouration.

Decuzzi, Article

IMAGE: Image courtesy of Daniele Di Mascolo. DESIGN: Bethany Vukomanovic.

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