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NMR measurements show that the interface between the inorganic and organic components can be tailored to design a highly conducting hybrid solid electrolyte.
While neutrophils are the first line of defence against infections and inflammation, their unrestricted recruitment and constant activation might result in prolonged inflammation and sharpening of specific pathological conditions. Here the authors develop a strategy to specifically target activated, pro-inflammatory neutrophils and neutrophil–platelet complexes to deliver therapeutics in the context of a murine model of venous thrombosis.
A phenylboronic acid-modified hetero-octameric Mycobacterium smegmatis porin A nanopore can directly distinguish 11 types of nucleoside monophosphates with a 0.996 accuracy.
Intrinsically stretchable quantum-dot-based semiconducting nanocomposites enable the realization of shape-tunable and colour-sensitive phototransistor arrays.
A non-volatile silicon photonics switch based on phase-change materials actuated by graphene heaters shows a switching energy density that is within an order of magnitude of the fundamental thermodynamic limit.
Magnetic skyrmions are topological spin textures that hold potential for the development of post-von Neumann computing schemes. In coupled ferrimagnetic insulators, pinning effects and intentional distortions can lead to a ratchet-like current-driven motion of skyrmion bubbles.
Li-metal surfaces can be effectively protected against corrosion using fluoroethylene carbonate, leading to a conformal and stable solid–electrolyte interphase.
Cell heterogeneity might impact the delivery of lipid nanoparticles (LNPs) and efficacy of messenger RNA-based therapies in vivo. Here, the authors propose an approach to measure how various LNPs deliver DNA barcodes and mRNA to cells using single-cell RNA sequencing, providing a correlation between LNP uptake and the expression of specific genes that characterize cellular subtypes.
A theoretical model captures the thermodynamic principles behind the functioning of an out-of-equilibrium photoactivated artificial molecular pump in a quantitative manner.
Nicotinamide adenine dinucleotide (NAD+) is an immune modulator that was suggested as a potential treatment for sepsis, but its in vivo benefits are contradictory and its low bioavailability as a free drug hampers potential clinical translation. Here the authors show that using a lipid-coated nanoparticle to deliver NAD+ to the cell cytosol can effectively replenish the intracellular content of NAD+ and reduce the extent of the inflammatory response in mouse models of sepsis.
Light harvesting in photosynthesis and photovoltaics may rely on quantum-coherent energy transfer, but experimental verification is hindered by the lossy nature of the molecular systems. Subnanometre-resolved electroluminescence spectroscopy now reveals wavelike intermolecular electronic energy transfer through quantum coherence in artificially constructed donor–acceptor heterodimers at the single-molecule level.
Nanostructured fibres with highly aligned and alternating crystalline and amorphous domains created from triblock copolymers exhibit excellent mechanical properties, multi-trigger actuation, high-performance contraction and on/off rotation.
An optical technique is developed that extends the capabilities of fluorescent nanosensors into previously inaccessible ultradeep in vivo locations, including the brain, without the use of fibre optic or cranial window insertion.
Activation of the STING pathway in antigen-presenting cells has been proposed as a strategy to stimulate the adaptive immune response against tumours, but its clinical application is hampered by the instability, low specificity and low cytosolic entry of natural STING agonists. Here the authors present a platform for targeted ultrasound-mediated cytosolic delivery of STING agonists that shows efficacy in different animal tumour models and improves the response to checkpoint blockade therapies.
A metal–organic-framework-derived nanoporous carbon with intrinsically fast sorption kinetics and excellent photothermal properties enables high-yield, solar-driven atmospheric water harvesting in arid areas.
Pyroptosis is a programmed cell death mechanism relevant in cancer therapy that can be triggered by endocytic organelle stress, but is challenging to induce in a controlled manner. In this paper the authors engineer a library of ultra-pH-sensitive nanophotosensitizers that can target specific endocytic organelles and elicit pyroptotic cancer cell death in a controlled fashion.
Biocompatible core–shell quantum dots and superconducting nanowire single-photon detector enable non-invasive one-photon excitation fluorescence imaging at 1,880 nm for in vivo imaging at 1,100 μm depth.
Friction and wear at the atomic scale are hard to capture in experiment. Real-time in situ investigations of the countermotion of two touching tungsten asperities by means of high-resolution transmission electron microscopy unveil discrete stick–slip friction and molecular dynamics simulations provide insights into the sliding pathway of the atoms at the interface.