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Atomically thin heterostructures function as optomemristors, which are used for biomimetic neural algorithms for performing winner-take-all tasks, such as competitive and cooperative learning.
An artificial ligament replacement is made from aligned carbon nanotubes formed into hierarchical helical fibres with nanometre and micrometre channels which are demonstrated for the replacement of anterior cruciate ligaments in both rabbit and ovine models, showing strong integration and functional recovery.
Optimizing the retention of drug delivery nanocarriers for improved cancer therapy has the potential to improve clinical outcomes. Here the authors screen 20 renal-clearable zwitterionic cyclodextrin-based nanocarriers for optimized biodistribution and tumour retention, demonstrating application in colorectal cancer models.
Monolayer MoS2 is grown at the back end of the line of 200 mm silicon CMOS wafers at a temperature of <300 °C, and hybrid silicon CMOS/MoS2 circuits are demonstrated through heterogeneous integration.
Floatable hydrogel nanocomposites, with facile intercalation of various photocatalysts, effectively produce hydrogen. The easily scalable nature of the nanocomposites demonstrates the practical application of this new type of photocatalytic platform.
Photonic Dirac metasurfaces with smooth trapping potentials guide optical modes endowed with pseudo-spin. Such potentials give rise to different radiative properties of modes of opposite pseudo-spin.
Intrinsic ferroelectricity in bilayer WTe2 can be used for electrical switching of the centred-rectangular moiré potential in WTe2/WSe2 heterostructures.
Wearable resistive sensors for biometrics and machine interfacing are often non-specific. Here the authors report on the creation of hierarchically resistive skins for monitoring physical or physiological activities around the throat which, with the use of neural networking, can be used to distinguish different activities.
Protease profiling of the tumour microenvironment using DNA-barcoded nanosensors and CRISPR amplification enables portable cancer diagnosis in preclinical models.
Inspired by the visual systems of agile insects, Chen et al. emulate their graded neurons using optoelectronic devices to realize bioinspired in-sensor motion perception and demonstrate high recognition accuracy with limited computational resources.
Operando synchrotron experiments reveal the Mn dissolution/redeposition dynamics in Mn-containing cathodes and offer insights into the regulation of Mn dissolution using ion-capturing polymers.
Systemic drug delivery to the bone marrow is limited, currently requiring high doses of drug, increasing the risk of side effects. Here, the authors report on the hitchhiking of drug nanoparticles in neutrophils using their natural homing to the bone marrow for targeted delivery, and demonstrate its application.
Understanding the pathways of nanoparticle removal from the body is important for nanomedicine applications and safety. Here the authors report the elimination of gold nanoparticles from the proximal tubules in the kidney via a newly described elimination pathway.
This study uncovers the role of aromatic clusters in the receptor extracellular loop of sialic-acid-binding immunoglobulin-like lectins that recognize carbon nanotubes and suggests inhibiting Syk signalling as a therapeutic intervention against inflammation.
Sonogenetics provides neuron-specific activation at high spatiotemporal resolution ex vivo in retina and in vivo deep in the visual cortex using the AAV gene delivery of a mechanosensitive ion channel and low-intensity ultrasound stimulations.
Ionic flow through ångström-scale channels facilitates selectivity beyond steric effects between ions of same charge and hydrated diameter. Here, with two-dimensional channels, the authors show that ion position in the channel influences selectivity.
Sensory signal attributes can be disentangled exploiting the computation-in-superposition capability of hyperdimensional computing, in-memory computing and associated intrinsic device-level stochasticity.
The crystallization of nanoparticles is observed with single-particle resolution via electron microscopy. The growth modes are explained via computer simulations, unifying the understanding of crystallization from the atomic to micrometre scale.
Approaches to treat inflammatory bowel disease with probiotics or artificial enzymes have advantages and limitations. Here we combine the advantages to overcome the individual limitations by modifying probiotics with artificial enzymes and demonstrate application in treating inflammatory bowel disease.