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Diet switching from high-fat to standard diet before influenza vaccination affects the metabolic state of T cells, restores their responses and improves vaccine efficacy in mice.
Artemisinin-resistant Plasmodium falciparum can use tRNA modification reprogramming and codon bias translation as an epitranscriptomic response to survive artemisinin-induced stress.
CryoEM of the Salmonella MS- and C-rings in a counterclockwise pose and the C-ring in clockwise poses reveal structural insight into the mechanisms of directional switches and torque transmission for the bacterial flagellar supercomplex.
Age-specific differences upon SARS-CoV-2 infection are marked by emergence of goblet 2 inflammatory cells expressing antiviral interferon stimulating genes in paediatric nasal cultures, and basaloid-like cells with increased viral spread in cultures from older adults.
The presence of multiple functional m6A modification sites on diverse HIV-1 RNA transcripts suggests a strategy to provide additional stability and resilience to HIV-1 replication.
Active infections of giant viruses in their marine protists hosts are tracked at single-cell resolution, showing that, despite being rare, these viruses still impact microbial population dynamics.
The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial cultures.
The authors propose a model for the mechanism underlying how a phage defence system remains primed for infection but tightly controlled to prevent host toxicity.
A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.
Carolina Rosadas explains why we need more research investigating human T lymphotropic virus type 1 (HTLV-1) infections, and why more public visibility is needed for those affected.
As the saying goes, sharing is caring — but when it comes to the data underlying primary research papers published at Nature Microbiology, sharing is also mandatory.
Longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period shows that microbes acquired from cow microbiomes introduce clinically relevant antimicrobial resistance genes to farmer guts.
Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
Virological, clinical and immunological characterization of a dengue virus 3 human challenge model could help with identifying vaccine and drug candidates.
GvpU regulates spatial organization of gas vesicles in the bacterial cytosol through tunable interactions with the core gas vesicle shell protein and phase transition, enabling future opportunities for engineering of cellular buoyancy.