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The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial cultures.
The authors propose a model for the mechanism underlying how a phage defence system remains primed for infection but tightly controlled to prevent host toxicity.
A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.
Carolina Rosadas explains why we need more research investigating human T lymphotropic virus type 1 (HTLV-1) infections, and why more public visibility is needed for those affected.
As the saying goes, sharing is caring — but when it comes to the data underlying primary research papers published at Nature Microbiology, sharing is also mandatory.
Longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period shows that microbes acquired from cow microbiomes introduce clinically relevant antimicrobial resistance genes to farmer guts.
Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
Virological, clinical and immunological characterization of a dengue virus 3 human challenge model could help with identifying vaccine and drug candidates.
GvpU regulates spatial organization of gas vesicles in the bacterial cytosol through tunable interactions with the core gas vesicle shell protein and phase transition, enabling future opportunities for engineering of cellular buoyancy.
Exposing cerebral organoids and post-mortem brain explants to SARS-CoV-2 virus particles alters expression of synaptic proteins and potentially affects synaptic function by blocking LPHN3 and FLRT3 synapses.
Laboratory and clinical strains of Crimean–Congo haemorrhagic fever virus use LDLR to bind and enter host cells in blood vessel organoids and mice. Infection can also occur through ApoE, possibly present on virus particles.
Cryo-EM analysis of the substrate-bound T9SS from Flavobacterium johnsoniae reveals an extended translocon complex and provides insight into protein secretion.
The FEAR pathway acts via FACT and ETS-1 and elicits antiviral responses against various DNA and RNA viruses independent of interferons, which are countered by poxvirus A51R proteins.
Extracellular vesicles carrying phosphatidylserine on their surface, found in large quantities in semen, saliva and breast milk, but not in blood, provide an innate defence strategy by blocking viral entry through competition for binding to cellular phosphatidylserine receptors, explaining why many viruses are transmitted by blood rather than by these body fluids.
Phosphatidylserine-exposing extracellular vesicles in body fluids can inhibit infection of viruses that use viral apoptotic mimicry for infection, but not viruses that use other entry mechanisms.
Integration of differential and conventional RNA sequencing and transposon mutant fitness data for Bacteroides thetaiotaomicron grown under 15 different conditions provides an expression atlas, expands the regulatory RNA repertoire and reveals that the small RNA MasB regulates susceptibility to tetracyclines.