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Millions of people have died from SARS-CoV-2. This Review summarizes how autopsies have contributed to our understanding of disease pathology, discusses the advantages and limitations of autopsies, and outlines how they complement animal infection experiments and clinical studies.
An outline of best practices, resources and suggested improvements to ensure that the complexities inherent to microbial big data do not hamper accessibility.
As more PhD students and postdoctoral fellows transition to professions outside academia, training programmes must prepare scientists for these alternative careers.
Genomic epidemiology of the Yemen cholera outbreak reveals the genetic basis for emergence of multidrug resistance with implications for Vibrio cholerae surveillance and control.
Genomic epidemiology of Vibrio cholerae isolates recovered between 2016 and 2019 during the Yemen cholera outbreak reveals acquisition of multidrug resistance and patterns of plasmid transmission between endemic and epidemic lineages.
Recovery and characterization of the wild-type pangolin coronavirus GD strain helps determine whether these viruses present risks for human transmission and an emerging threat to public health.
Culture-independent CRISPR spacer screens enable the discovery of hundreds of viruses and mobile genetic elements infecting all known methanogenic lineages.
Pangolin coronavirus GD has reduced replication and transmission fitness compared with SARS-CoV-2, and therapies approved for SARS-CoV-2 are effective against this virus.
Detection of poliovirus by cell culture and subsequent serotype identification via Sanger sequencing can be slow, delaying responses to emerging outbreaks. Direct virus detection using nested reverse transcription PCR and nanopore sequencing was prospectively validated in the Democratic Republic of the Congo and yielded accurate results in a fraction of the time.
Dietary fibre deprivation in mice increases the abundance of gut microbial mucin-degrading species, leads to barrier dysfunction and increases local type 2 inflammation. In a tractable human microbiota mouse model, the presence of Akkermansia muciniphila results in increased anti-commensal IgE and type 2 immune responses, worsening food allergy symptoms following sensitization.
Genetic and phenotypic changes that enable Pseudomonas to adapt to an animal host are identified. These traits are controlled by a universal signalling molecule and are shared by diverse strains.