Image concept provided by Anna-Louise Reysenbach, Alison E. Murray, Brian P. Hedlund and graphics created by Sophie Baker, Desert Research Institute

Naming uncultivated Archaea and Bacteria

Latest Research

  • Article |

    This study describes design automation and predictable gene regulatory network engineering in a eukaryotic microorganism.

    • Ye Chen
    • , Shuyi Zhang
    • , Eric M. Young
    • , Timothy S. Jones
    • , Douglas Densmore
    •  & Christopher A. Voigt
  • Article |

    This study describes the mechanism by which Chlamydia trachomatis reprogrammes host glutamine metabolism in a c-Myc-dependent manner. The authors show that glutamine uptake via the SLC15A transporter and glutaminolysis are crucial for peptidoglycan synthesis and Chlamydia replication.

    • Karthika Rajeeve
    • , Nadine Vollmuth
    • , Sudha Janaki-Raman
    • , Thomas F. Wulff
    • , Apoorva Baluapuri
    • , Francesca R. Dejure
    • , Claudia Huber
    • , Julian Fink
    • , Maximilian Schmalhofer
    • , Werner Schmitz
    • , Rajeeve Sivadasan
    • , Elmar Wolf
    • , Wolfgang Eisenreich
    • , Almut Schulze
    • , Jürgen Seibel
    •  & Thomas Rudel
  • Article |

    In this manuscript, the authors address evolutionary questions on the emergence of SARS-CoV-2. They find that SARS-CoV-2 is not a recombinant of any sarbecoviruses detected to date, and that the bat and pangolin sequences most closely related to SARS-CoV-2 probably diverged several decades ago or possibly earlier from human SARS-CoV-2 samples.

    • Maciej F. Boni
    • , Philippe Lemey
    • , Xiaowei Jiang
    • , Tommy Tsan-Yuk Lam
    • , Blair W. Perry
    • , Todd A. Castoe
    • , Andrew Rambaut
    •  & David L. Robertson
  • Letter |

    Subinhibitory levels of sulfamethoxazole, an antibiotic used to treat Escherichia coli infections, trigger a previously undescribed metabolic pathway in E. coli that comprises a family of hybrid pterin–phenylpyruvate conjugates called colipterins. These metabolites are antioxidants, have immunomodulatory properties and improve colitis in a murine model.

    • Hyun Bong Park
    • , Zheng Wei
    • , Joonseok Oh
    • , Hao Xu
    • , Chung Sub Kim
    • , Rurun Wang
    • , Thomas P. Wyche
    • , Grazia Piizzi
    • , Richard A. Flavell
    •  & Jason M. Crawford
  • Article |

    This study reveals features of Epstein–Barr virus that are similar but not identical to the closely related Kaposi’s sarcoma-associated herpesvirus. The authors provide locations of protein components within the viral capsid and reveal different conformers of protein components by revealing variations in links between capsid proteins and exploiting approaches with relaxation of symmetry. The capsid-associated tegument complex is loaded on to the capsid with long-range asymmetry, relative to the location of the portal vertex (the site of genome entry and egress).

    • Wei Liu
    • , Yanxiang Cui
    • , Caiyan Wang
    • , Zihang Li
    • , Danyang Gong
    • , Xinghong Dai
    • , Guo-Qiang Bi
    • , Ren Sun
    •  & Z. Hong Zhou
  • Article |

    This study reveals that prion-like domains support the assembly of transcription factor complexes that control fungal cell identity and highlights parallels with the ‘super-enhancers’ that regulate mammalian cell fate.

    • Corey Frazer
    • , Mae I. Staples
    • , Yoori Kim
    • , Matthew Hirakawa
    • , Maureen A. Dowell
    • , Nicole V. Johnson
    • , Aaron D. Hernday
    • , Veronica H. Ryan
    • , Nicolas L. Fawzi
    • , Ilya J. Finkelstein
    •  & Richard J. Bennett

News & Comment

  • News & Views |

    Iron-scavenging molecules called siderophores that are produced by the native microbial residents of plant roots fend off plant pathogens such as Ralstonia solanacearum.

    • Shaul Pollak
    •  & Otto X. Cordero
  • News & Views |

    A virus has been found inserted into the genome of the most abundant bacteria in the oceans. Even though the virus can kill its host, the genes carried by the prophage may help these bacteria flourish around the world.

    • David L. Kirchman
  • News & Views |

    A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.

    • Ursula Theuretzbacher
  • News & Views |

    Marine bacteria that produce an enormous panoply of glycan-degrading enzymes are identified as having a role in releasing fixed carbon present in glycan-rich cell walls of brown algae.

    • Fiona Cuskin
    •  & Elisabeth C. Lowe

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