Current Issue
Tobias Wüstefeld

Current Issue

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Latest Research

  • Review Article |

    This Review Article examines how microorganisms that have key roles in the ocean carbon and nitrogen cycles may respond to anthropogenic changes in the Earth's marine ecosystems.

    • David A. Hutchins
    •  & Feixue Fu
  • Perspective |

    In this Perspective, Suez and Elinav describe the potential for therapeutic approaches based on the use of metabolites secreted, modulated or degraded by the gut microbiome, and issues that will be critical for their implementation.

    • Jotham Suez
    •  & Eran Elinav
  • Letter |

    When faced with hypoxic conditions, Mycobacterium tuberculosis adapts its metabolism to generate intermediates reserved for re-initiation of peptidoglycan biosynthesis that can be used as soon as it is re-exposed to normoxia.

    • Hyungjin Eoh
    • , Zhe Wang
    • , Emilie Layre
    • , Poonam Rath
    • , Roxanne Morris
    • , D. Branch Moody
    •  & Kyu Y. Rhee
  • Article |

    Nitric oxide deficiency promotes tuberculosis through increased neutrophilic inflammation.

    • Bibhuti B. Mishra
    • , Rustin R. Lovewell
    • , Andrew J. Olive
    • , Guoliang Zhang
    • , Wenfei Wang
    • , Eliseo Eugenin
    • , Clare M. Smith
    • , Jia Yao Phuah
    • , Jarukit E. Long
    • , Michelle L. Dubuke
    • , Samantha G. Palace
    • , Jon D. Goguen
    • , Richard E. Baker
    • , Subhalaxmi Nambi
    • , Rabinarayan Mishra
    • , Matthew G. Booty
    • , Christina E. Baer
    • , Scott A. Shaffer
    • , Veronique Dartois
    • , Beth A. McCormick
    • , Xinchun Chen
    •  & Christopher M. Sassetti

News & Comment

  • News and Views |

    Structural and functional studies of the archaeum Methanocaldococcus jannaschii Argonaute (MjAgo) reveal a DNA-guided DNA nuclease that is also active without a guide. This unguided activity is suggested to prime MjAgo for its subsequent sequence-specific DNA-silencing role in host defence.

    • Lennart Randau
  • News and Views |

    The antimalarial mefloquine has been used in the clinic for decades, yet its mode of action has remained elusive. Now, a study reports that the enantiomer (+)-mefloquine binds to the cytosolic ribosome of the major malaria parasite Plasmodium falciparum.

    • Jeremy Burrows
  • News and Views |

    Flaviviruses stimulate cross-reactive immune responses that may reduce or exacerbate manifestations of subsequent flavivirus infection. Recent work demonstrates that cross-reactive T cells protect against Zika in HLA transgenic mice, a key step in the development of safe and effective vaccines.

    • Matthew Collins
    •  & Aravinda de Silva
  • News and Views |

    Structural analysis of the mycobacterial ESX-5 secretion complex presents an important step towards understanding how the ESX type VII (T7) secretion systems can translocate a multitude of substrates — including virulence factors involved in pathogenesis — across the bacterial cell envelope.

    • Tracy Palmer
  • Editorial |

    From roles in the health, nutrition and performance of humans during spaceflight, through to the question of life on other worlds, microbiology has fundamental contributions to make to our exploration of the cosmos.

  • Q&A |

    We asked microbiologist and NASA astronaut Kate Rubins about her time on the International Space Station, the challenges of working with bugs in space, and what's next for science that is out of this world.

    • Emily White

Current Issue

Volume 2 Issue 6

Image: Tobias Wüstefeld, Cover Design: Samantha Whitham

Volume 2 Issue 6

Exit route  

Single-particle analysis of cryo-electron microscopy structures elucidates the membrane complex of the mycobacterial ESX-5 type VII secretion system. This secretion pathway is used to deliver virulence factors from the bacterial cytoplasm into the host cell through a channel in the bacterial inner membrane. 

See Beckham et al. 2, 17047 (2017)

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