Current Issue
Markus Ganter

Current Issue

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Latest Research

  • Letter |

    When faced with hypoxic conditions, Mycobacterium tuberculosis adapts its metabolism to generate intermediates reserved for re-initiation of peptidoglycan biosynthesis that can be used as soon as it is re-exposed to normoxia.

    • Hyungjin Eoh
    • , Zhe Wang
    • , Emilie Layre
    • , Poonam Rath
    • , Roxanne Morris
    • , D. Branch Moody
    •  & Kyu Y. Rhee
  • Article |

    Nitric oxide deficiency promotes tuberculosis through increased neutrophilic inflammation.

    • Bibhuti B. Mishra
    • , Rustin R. Lovewell
    • , Andrew J. Olive
    • , Guoliang Zhang
    • , Wenfei Wang
    • , Eliseo Eugenin
    • , Clare M. Smith
    • , Jia Yao Phuah
    • , Jarukit E. Long
    • , Michelle L. Dubuke
    • , Samantha G. Palace
    • , Jon D. Goguen
    • , Richard E. Baker
    • , Subhalaxmi Nambi
    • , Rabinarayan Mishra
    • , Matthew G. Booty
    • , Christina E. Baer
    • , Scott A. Shaffer
    • , Veronique Dartois
    • , Beth A. McCormick
    • , Xinchun Chen
    •  & Christopher M. Sassetti
  • Article |

    Cryo-electron microscopy of the tripartite MacA–MacB–TolC multidrug transporter.

    • Anthony W. P. Fitzpatrick
    • , Salomé Llabrés
    • , Arthur Neuberger
    • , James N. Blaza
    • , Xiao-Chen Bai
    • , Ui Okada
    • , Satoshi Murakami
    • , Hendrik W. van Veen
    • , Ulrich Zachariae
    • , Sjors H. W. Scheres
    • , Ben F. Luisi
    •  & Dijun Du
  • Article |

    Metabolomics analyses of Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae show that, unlike other metabolites, coenzymes such as pyridoxal 5'-phosphate, NAD(P), coenzyme A and flavins are long-lived in vivo and passed on over generations.

    • Johannes Hartl
    • , Patrick Kiefer
    • , Fabian Meyer
    •  & Julia A. Vorholt

News & Comment

  • News and Views |

    RIPK3 is a well-known mediator of the necroptosis cell death pathway, which is an important antiviral defence mechanism. In an unexpected twist, RIPK3 has now been shown to also drive neuroprotective inflammation in the central nervous system during West Nile virus infection in a cell-death-independent manner.

    • Katherine B. Ragan
    •  & Jason W. Upton
  • News and Views |

    It is unclear why pregnant women are at high risk of severe influenza infection. Allogeneic pregnancy in mice is now shown to alter both innate and adaptive responses to influenza virus infection, enabling the emergence of more virulent virus variants.

    • Elodie Ghedin
    •  & Stacey Schultz-Cherry
  • Editorial |

    If we are to be successful in keeping priority pathogens at bay in the long term, global responses to antimicrobial resistance should embrace and fund innovative therapeutic strategies that are developed in the basic microbiology laboratory.

  • News and Views |

    Bacterial specialized metabolites are bioactive molecules with antibacterial or other activities that are of tremendous clinical use. New work has revealed that transcript elongation is a distinct and widespread point of secondary metabolic gene regulation, which has implications for expanding drug discovery.

    • Justin R. Nodwell

Current Issue

Volume 2 Issue 5

Image: Markus Ganter, Cover Design: Samantha Whitham

Volume 2 Issue 5

Cycle proficiency

In the pathogenic blood stage of infection, Plasmodium falciparum cell-cycle progression is directed by the parasite-specific kinase CRK4. Without active CRK4, DNA replication is inhibited and the nuclei are deformed by spindle-like structures.

See Ganter et al. 2, 17017 (2017)

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