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Latest Research

  • Article |

    A structural analysis of the C-terminal extension of DotL and its binding partners DotN, IcmS, IcmW and LvgA elucidates how the type IV secretion system (T4SS) of Legionella pneumophila mediates the recruitment of T4SS effectors.

    • Mi-Jeong Kwak
    • , J. Dongun Kim
    • , Hyunmin Kim
    • , Cheolhee Kim
    • , James W. Bowman
    • , Seonghoon Kim
    • , Keehyoung Joo
    • , Jooyoung Lee
    • , Kyeong Sik Jin
    • , Yeon-Gil Kim
    • , Nam Ki Lee
    • , Jae U. Jung
    •  & Byung-Ha Oh
  • Article |

    A lack of models has hindered the study of Ebola virus (EBOV) persistence and sequelae, which are now shown to occur in rhesus monkeys. Progressive EBOV spread into eyes, brain and testes with CD68+ cells as the cryptic EBOV reservoir.

    • Xiankun Zeng
    • , Candace D. Blancett
    • , Keith A. Koistinen
    • , Christopher W. Schellhase
    • , Jeremy J. Bearss
    • , Sheli R. Radoshitzky
    • , Shelley P. Honnold
    • , Taylor B. Chance
    • , Travis K. Warren
    • , Jeffrey W. Froude
    • , Kathleen A. Cashman
    • , John M. Dye
    • , Sina Bavari
    • , Gustavo Palacios
    • , Jens H. Kuhn
    •  & Mei G. Sun
  • Letter |

    Whether phage genetic mosaicism generates a spectrum of diversity or discrete populations is unclear. Two phage evolutionary modes are described here that differ in the extent of horizontal gene transfer depending on host, lifestyle and genetic constitution

    • Travis N. Mavrich
    •  & Graham F. Hatfull
  • Letter |

    This study reports the structure of hRSV NS1, identifying unique regions that modulate host gene expression and contribute to inhibition of the IFN-I pathway and of dendritic cell maturation, pointing to new avenues of hRSV attenuation.

    • Srirupa Chatterjee
    • , Priya Luthra
    • , Ekaterina Esaulova
    • , Eugene Agapov
    • , Benjamin C. Yen
    • , Dominika M. Borek
    • , Megan R. Edwards
    • , Anuradha Mittal
    • , David S. Jordan
    • , Parameshwar Ramanan
    • , Martin L. Moore
    • , Rohit V. Pappu
    • , Michael J. Holtzman
    • , Maxim N. Artyomov
    • , Christopher F. Basler
    • , Gaya K. Amarasinghe
    •  & Daisy W. Leung
  • Article |

    Development of a broad-spectrum β-lactamase inhibitor capable of combatting multidrug-resistant pathogens, including Acinetobacter baumannii.

    • Thomas F. Durand-Réville
    • , Satenig Guler
    • , Janelle Comita-Prevoir
    • , Brendan Chen
    • , Neil Bifulco
    • , Hoan Huynh
    • , Sushmita Lahiri
    • , Adam B. Shapiro
    • , Sarah M. McLeod
    • , Nicole M. Carter
    • , Samir H. Moussa
    • , Camilo Velez-Vega
    • , Nelson B. Olivier
    • , Robert McLaughlin
    • , Ning Gao
    • , Jason Thresher
    • , Tiffany Palmer
    • , Beth Andrews
    • , Robert A. Giacobbe
    • , Joseph V. Newman
    • , David E. Ehmann
    • , Boudewijn de Jonge
    • , John O'Donnell
    • , John P. Mueller
    • , Rubén A. Tommasi
    •  & Alita A. Miller
  • Letter |

    The undulating surface of mycobacterial cells contains wave troughs inherited from the (grand)mother cell that, combined with chromosome positioning, determine the site where cell division takes place.

    • Haig A. Eskandarian
    • , Pascal D. Odermatt
    • , Joëlle X. Y. Ven
    • , Mélanie T. M. Hannebelle
    • , Adrian P. Nievergelt
    • , Neeraj Dhar
    • , John D. McKinney
    •  & Georg E. Fantner

News & Comment

  • Editorial |

    The WHO's plans to bolster global vector control measures blend audacious goals with a sensible approach that could save lives and stimulate economic growth and development in many of the world's poorest nations.

  • News and Views |

    Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals that instead of directing an antibacterial killing response, nitric oxide is critical for restraining granulocytic inflammation, which can provide a nutrient-rich niche for increased bacterial growth.

    • Christina L. Stallings
  • Comment |

    In many countries, the success of misinformation, alternative facts or fake news is promoting a climate of science denial, where false claims such as vaccination causing autism can spread. Learning lessons from behavioural studies can help advocate for vaccination in the face of vaccine refusers and deniers.

    • Cornelia Betsch
  • News and Views |

    Plants respond to microbial attack with a lethal burst of reactive oxygen species. How then, do pathogens successfully invade plants? Unexpectedly, a link between primary metabolism and suppression of plant immunity allows the rice blast fungus Magnaporthe oryzae to grow in such a hostile environment.

    • Antonio Di Pietro
    •  & Nicholas J. Talbot
  • News and Views |

    Coenzymes serve as the catalytic core in many metabolic reactions, but despite their extensive use and intrinsic chemical reactivity, they are remarkably stable.

    • Jens Nielsen
  • News and Views |

    Structural and functional studies of the archaeum Methanocaldococcus jannaschii Argonaute (MjAgo) reveal a DNA-guided DNA nuclease that is also active without a guide. This unguided activity is suggested to prime MjAgo for its subsequent sequence-specific DNA-silencing role in host defence.

    • Lennart Randau

Current Issue

Volume 2 Issue 7

Image: Ella Maru Studio, Cover Design: Karen Moore

Volume 2 Issue 7

Sending signals

Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation. 

See van Wijk et al2, 17066 (2017) and Noad et al2, 17063 (2017)

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