Volume 6 Issue 2, February 2000
During cardiac hypertrophy, myocytes undergo sarcomeric reorganization, but little is known about the signaling pathways that convert extracellular stimuli into cellular structural changes. In an article on page 183, Aoki et al. demonstrate that hypertrophic signals activate the calcium/calmodulin pathway and myosin light chain phosphorylation, leading to sarcomere formation. The cover image shows sarcomeres in cardiac myocytes after treatment with a variety of calcium/calmodulin or myosin light chain kinase inhibitors.
Editorial
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