Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Leaky vessels? Call Ang1!

Abstract

Recent findings suggest that combined administration of the angiogenic factors Ang1 and VEGF may improve current therapeutic approaches for inducing formation of new blood vessels. However, many questions remain about the mechanisms of these factors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Determinants of angiogenesis and vascular permeability.

References

  1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27–31 (1995).

    Article  CAS  Google Scholar 

  2. Hanahan, D. Signaling vascular morphogenesis and maintenance. Science 277, 48–50 (1997).

    Article  CAS  Google Scholar 

  3. Detmar, M. et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J. Invest. Dermatol. 111, 1–6 (1998).

    Article  CAS  Google Scholar 

  4. Suri, C. et al. Increased vascularization in mice overexpressing angiopoietin-1. Science 282, 468–471 (1998).

    Article  CAS  Google Scholar 

  5. Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511–2514 (1999).

    Article  CAS  Google Scholar 

  6. Dvorak, H.F. et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029–1039 (1995).

    CAS  Google Scholar 

  7. Roberts, W.G. & Palade, G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108, 2369–2379 (1995).

    CAS  Google Scholar 

  8. Hobbs, S.K. et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA 95, 4607–4612 (1998).

    Article  CAS  Google Scholar 

  9. Monsky, W.L. et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res. 59, 4129–4135 (1999).

    CAS  Google Scholar 

  10. Fukumura, D. et al. Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. Am. J. Pathol. 150, 679–688 (1997).

    Google Scholar 

  11. Patan, S., Munn, L.L. & Jain, R.K. Intussusceptive microvascular growth in solid tumors: a novel mechanism of tumor angiogenesis. Microvasc. Res. 51, 260–272 (1996).

    Article  CAS  Google Scholar 

  12. Carmeliet, P. & Collen D. Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development. Curr. Top. Microbiol. Immunol. 237, 133–158 (1999).

    CAS  Google Scholar 

  13. Ferrara, N. & Alitalo, K. Clinical applications of angiogenic growth factors and their inhibitors. Nature Med. 5, 1359–1364 (1999).

    Article  CAS  Google Scholar 

  14. Baumgartner, I. et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97, 1114–1123 (1998).

    Article  CAS  Google Scholar 

  15. Melder, R.J. et al. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Med. 2, 992–997 (1996).

    Article  CAS  Google Scholar 

  16. Gale, N.G. & Yancopoulos, G.D. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins and ephrins in vascular development. Genes Dev. 13, 1055–1066 (1999).

    Article  CAS  Google Scholar 

  17. Yuan, F. et al. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 54, 4564–4568 (1994).

    CAS  Google Scholar 

Download references

Acknowledgements

We thank D. Fukumura, C. Mouta Carreira, M. Detmar, B. Seed, B. Fenton and J. Samson for their input.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jain, R., Munn, L. Leaky vessels? Call Ang1!. Nat Med 6, 131–132 (2000). https://doi.org/10.1038/72212

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/72212

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing