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New feelings about the role of sensory nerves in inflammation

Nature Medicine volume 6, pages 134–135 (2000)Cite this article

Abstract

The pro-inflammatory agents trypsin and mast cell tryptase cleave and activate proteinase-activated receptor 2 (PAR2), which is expressed on sensory nerves, explaining a previously unknown mechanism in neurogenic inflammation (151–158).

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Figure 1: Sensory nerves may be activated through the following endogenous mechanisms1: Heat activates the vanilloid VR1 receptor; protons may also activate/sensitize this receptor2.

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  1. Centre for Cardiovascular Biology & Medicine, New Hunt's House, GKT School of Biomedical Sciences, King's College, Guy's Campus, London, SE1 1UL, UK

    Susan D. Brain

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  1. Susan D. Brain
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Brain, S. New feelings about the role of sensory nerves in inflammation. Nat Med 6, 134–135 (2000). https://doi.org/10.1038/72218

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