Reviews & Analysis

Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.

A comprehensive review of the current literature on post-acute COVID-19, also referred to as long COVID, its pathophysiology and its organ-specific sequelae highlights the need for multidisciplinary follow-up and care of COVID-19 survivors.

A large genomic surveillance effort in South Africa produced 1,365 high-quality whole genomes of SARS-CoV-2; this has identified 16 new lineages of the virus that had not been identified in other countries.

Global coordination of public health efforts will be needed to defeat the COVID-19 pandemic and to prepare for future public health emergencies.

As the emergence of viral diseases is expected to accelerate, proactive programs to develop broadly active family-specific and cross-family antiviral therapeutics will be key to prepare for future disease outbreaks.

All countries worldwide have signed up to the United Nations Sustainable Development Goals and committed to the objective of achieving universal health coverage. Getting there will require understanding how packages of essential health services can be developed in resource-constrained settings and how experts and the public can make decisions about which health services should be provided free of charge.

Recent advances in computational and laboratory sciences are helping researchers to address large-scale sustained emergencies, such as the COVID-19 pandemic, and constantly adapt to the emergence of new questions, data and findings in order to synthesize real-time evidence that will inform policy decisions.

Antisense oligonucleotides that target lamin A/C pre-mRNA decrease both progerin transcript levels and progerin protein levels and extend lifespan in an animal model of Hutchinson–Gilford progeria syndrome.

An analysis of life expectancy and cause of death in 363 Latin American cities unveils wide differences between cities in the same country, and sheds light on the socioeconomic factors that determine how long people live and how they die.

Single-cell RNA-sequencing can help in the prediction of drug resistance in patients with multiple myeloma.

The many levels of heterogeneity within tumors dictate their response to therapy and should be considered in future therapeutic regimes.

Models of estrogen receptor–positive breast cancer are used to explore the rationale for androgen receptor agonists as treatments for breast cancer.

People on low-fat, low-energy-density diets have lower ad libitum energy intake than that of those on high-fat, high-energy-density diets.

CRISPR-Cas gene editing enters the field of promising clinical approaches for mitigating hemoglobin defects in patients with hemoglobinopathies.

New personalized brain-stimulation methods for the treatment of depression and obsessive–compulsive symptoms provide hope for future treatment applications.

A comprehensive strategy for the next steps to ensure vaccination of the global population against SARS-CoV-2 is now required, and key steps and challenges are detailed in this Perspective.

An algorithm developed through machine learning on existing radiological data from diverse people has the potential to improve the diagnosis and management of knee pain from osteoarthritis and reduce racial disparities in the assessment of knee pain.

Analysis of glycemic and non-glycemic characteristics in individuals at risk for type 2 diabetes identifies six putative subgroups that differ in terms of risk of diabetes progression and complications.

Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8⁺ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.

The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.