Single-cell RNA-sequencing can help in the prediction of drug resistance in patients with multiple myeloma.
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References
National Cancer Institute Surveillance, Epidemiology, and End Results Program. https://seer.cancer.gov/statfacts/html/mulmy.html (accessed 20 January 2021).
Kumar, S. K. & Rajkumar, S. V. Nat. Rev. Clin. Oncol. 15, 409–421 (2018).
Nunnelee, J. Z. Q. et al. Blood 134, 4573 (2019).
Thorsteinsdottir, S. et al. Haematologica 103, e412–e415 (2018).
Liu, Y., Tang, C. H., Qiu, H., Siggins, S. & Hou, H. A. Sci. Rep. 11, 1112 (2021).
Pinto, V. et al. Cancers (Basel) 12, 407 (2020).
Kumar, S. K. et al. Leukemia 26, 149–157 (2012).
Cohen, Y.C. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01232-w (2021).
The Multiple Myeloma Research Foundation. https://themmrf.org/finding-a-cure/our-work/the-mmrf-commpass-study/ (2019 accessed 20 January 2021).
Kuiper, R. et al. Blood 126, 1996–2004 (2015).
Oberle, A. et al. Haematologica 102, 1105–1111 (2017).
Scheijen, B. et al. Leukemia 33, 2227–2240 (2019).
Gooding, S. et al. Blood 137, 232–237 (2021).
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I.G. has a consulting and advisory role with Celgene, Takeda, Bristol-Myers Squibb, Genentech, Janssen Pharmaceuticals and Amgen, and has received research funding/honoraria from Celgene, Takeda, Bristol-Myers Squibb, Janssen Pharmaceuticals and Amgen. G.G. receives research funds from IBM and Pharmacyclics; is an inventor on patent applications related to MuTect, ABSOLUTE, MutSig, MSMuTect, MSMutSig, MSIdetect, POLYSOLVER and TensorQTL; and is a founder and consultant of and holds privately held equity in Scorpion Therapeutics.
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Sklavenitis-Pistofidis, R., Getz, G. & Ghobrial, I. Single-cell RNA sequencing: one step closer to the clinic. Nat Med 27, 375–376 (2021). https://doi.org/10.1038/s41591-021-01276-y
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DOI: https://doi.org/10.1038/s41591-021-01276-y
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