News & Views

In utero stem cell transplantation for inherited blood cell disorders.

A new minimally invasive device for the treatment of cerebral aneurysms called the Guglielmi detachable coil (CDC) system is described. A brief history of aneurysm treatment and the advantages of the new system are reported.

The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.

Stowaway stem cells in liver contribute to immunological tolerance in patients receiving liver transplants (pages 198–203).

The disappearance of genetically modified CTLs following infusion into AIDS patients led to a surprising observation: What are the implications for active immunotherapy (pages 216–223)?

A coagulation factor expressed in human breast cancer has implications for the interaction of neoplastic cells with vascular endothelium (pages 209–215).

Simple cost-effective strategies for genetic testing of HNPCC are proposed (pages 169–174), but many questions must be answered before testing for inherited forms of common cancers becomes a widespread reality.

Recent research suggests that cells respond to electromagnetic fields in the same was as they do to other environmental stresses.

New findings suggest that there are multiple inhibitory signals for regenerating neurons.

The presence of a specific amyloid β-protein in the brains of Down's syndrome patients suggests a common etiological pathway with the development of Alzheimer's disease-related neuropathology (pages 93–95).

Could immunization against cocaine be a viable prophylaxis for cocaine addiction?

Advances in cell transplantation and material sciences are being combined to create more biocompatible tissue engineered medical devices (pages 90–93).

Yet another mouse deafness gene encodes an unconventional myosin isozyme.

It is possible that growth hormone can offer therapeutic benefits for treating some forms of heart failure.

Family studies demonstrate population variation and genetic control in the CD4/CD8 ratio (pages 1279–1283).

It is difficult to show that patients' results on the most common quantitative test for sleepiness correlate with several factors associated with sleepiness.

A recently described mutation in the rod photoreceptor ion channel gene leading to retinitis pigmentosa suggests a mechanism for retinal degeneration.

Recent data suggest that deregulation of the restriction point in the cell-cycle G1 phase appears to be required for the development of neoplasias.

Computer simulations of theoretical models provide a way to elucidate mechanisms underlying neurological disorders and drug actions.

Cyclin D1 may be overexpressed in most breast cancers. Is this a critical early step in breast carcinogenesis (pages 1257–1260)?