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  • It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)

    • Giuseppe Pantaleo
    • Anthony S. Fauci
    News & Views
  • Examination of the effects of three new drugs shows that the destruction of the immune system in AIDS reflects fulminant HIV production, which eventually overwhelms the immune system's prodigious powers of regeneration.

    • Nicholas Short
    News & Views
  • Three articles claim to have identified the spinal muscular atrophy gene, yet they do not appear to have enough in common to identify the same gene.

    • T. Conrad Gilliam
    News & Views
  • Skinner and colleagues (pages 69–73) show that MRI can be used to evaluate atherosclerotic lesions, non-invasively and in vivo

    • Peter Libby
    News & Views
  • By careful microscopic examination of in vitro fertilization (pages 47–52) Simerly et al. demonstrate the paternal origin of the human centrosome and reveal steps at which fertilization may fail.

    • Tim Stearns
    News & Views
  • Two recent reports provide further evidence for a link between coxsackieviruses and the onset of IDDM, although a careful examination suggests it is still too early to conclude a definitive role.

    • Michele Solimena
    • Pietro De Camilli
    News & Views
  • For many years cholesterol was seen as the worst enemy of coronary arteries. Recent advances show that interactions between lipoproteins, coagulation and growth factors are important in atherosclerosis.

    • Michael R. Hayden
    • Michael Reidy
    News & Views
  • The demonstration, by Rutkowski et al. (page 80), that human Schwann cells can now be expanded to around 1 × 108 cells, provides a new opportunity for the study and therapy of myelin disorders.

    • Hugo W. Moser
    News & Views
  • Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target cells?

    • Ronald G. Crystal
    News & Views
  • Further progress in organ transplantation must overcome two key problems: a shortage of organs and long term immunological tolerance. Xenografts and immunological conditioning may help

    • R. Y. Calne
    News & Views