Supplementing the diet of ob/ob female mice with leptin not only reduces fat mass, but restores fertility.
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Hamilton, B. A new role for a fat actor. Nat Med 2, 272–273 (1996). https://doi.org/10.1038/nm0396-272
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DOI: https://doi.org/10.1038/nm0396-272
Further reading
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Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients
Kidney International (1997)