Articles

  • Article |

    Cross-study analysis defines fecal microbial species associated with colorectal cancer.

    • Jakob Wirbel
    • , Paul Theodor Pyl
    • , Ece Kartal
    • , Konrad Zych
    • , Alireza Kashani
    • , Alessio Milanese
    • , Jonas S. Fleck
    • , Anita Y. Voigt
    • , Albert Palleja
    • , Ruby Ponnudurai
    • , Shinichi Sunagawa
    • , Luis Pedro Coelho
    • , Petra Schrotz-King
    • , Emily Vogtmann
    • , Nina Habermann
    • , Emma Niméus
    • , Andrew M. Thomas
    • , Paolo Manghi
    • , Sara Gandini
    • , Davide Serrano
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Levi Waldron
    • , Alessio Naccarati
    • , Nicola Segata
    • , Rashmi Sinha
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    •  & Georg Zeller
  • Article |

    A small molecule that restores the integrity of the intestinal barrier provides a novel therapeutic strategy for inflammatory bowel diseases.

    • W. Vallen Graham
    • , Weiqi He
    • , Amanda M. Marchiando
    • , Juanmin Zha
    • , Gurminder Singh
    • , Hua-Shan Li
    • , Amlan Biswas
    • , Ma. Lora Drizella M. Ong
    • , Zhi-Hui Jiang
    • , Wangsun Choi
    • , Harmon Zuccola
    • , Yitang Wang
    • , James Griffith
    • , Jingshing Wu
    • , Harry J. Rosenberg
    • , Yingmin Wang
    • , Scott B. Snapper
    • , David Ostrov
    • , Stephen C. Meredith
    • , Lawrence W. Miller
    •  & Jerrold R. Turner
  • Article |

    Multicohort analysis identifies microbial signatures of colorectal cancer in fecal microbiomes.

    • Andrew Maltez Thomas
    • , Paolo Manghi
    • , Francesco Asnicar
    • , Edoardo Pasolli
    • , Federica Armanini
    • , Moreno Zolfo
    • , Francesco Beghini
    • , Serena Manara
    • , Nicolai Karcher
    • , Chiara Pozzi
    • , Sara Gandini
    • , Davide Serrano
    • , Sonia Tarallo
    • , Antonio Francavilla
    • , Gaetano Gallo
    • , Mario Trompetto
    • , Giulio Ferrero
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Jakob Wirbel
    • , Petra Schrotz-King
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    • , Georg Zeller
    • , Francesca Cordero
    • , Emmanuel Dias-Neto
    • , João Carlos Setubal
    • , Adrian Tett
    • , Barbara Pardini
    • , Maria Rescigno
    • , Levi Waldron
    • , Alessio Naccarati
    •  & Nicola Segata
  • Article |

    An integrated high-dimensional measurement of immune age describes a person’s immune status better than chronological age and predicts all-cause mortality.

    • Ayelet Alpert
    • , Yishai Pickman
    • , Michael Leipold
    • , Yael Rosenberg-Hasson
    • , Xuhuai Ji
    • , Renaud Gaujoux
    • , Hadas Rabani
    • , Elina Starosvetsky
    • , Ksenya Kveler
    • , Steven Schaffert
    • , David Furman
    • , Oren Caspi
    • , Uri Rosenschein
    • , Purvesh Khatri
    • , Cornelia L. Dekker
    • , Holden T. Maecker
    • , Mark M. Davis
    •  & Shai S. Shen-Orr
  • Article |

    Defects in the regulation of leptin gene expression can lead to a hypoleptinemic, leptin-responsive form of obesity.

    • Olof S. Dallner
    • , Jill M. Marinis
    • , Yi-Hsueh. Lu
    • , Kivanc Birsoy
    • , Emory Werner
    • , Gulya Fayzikhodjaeva
    • , Brian D. Dill
    • , Henrik Molina
    • , Arden Moscati
    • , Zoltán Kutalik
    • , Pedro Marques-Vidal
    • , Tuomas O. Kilpeläinen
    • , Niels Grarup
    • , Allan Linneberg
    • , Yinxin Zhang
    • , Roger Vaughan
    • , Ruth J. F. Loos
    • , Mitchell A. Lazar
    •  & Jeffrey M. Friedman
  • Article |

    Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors.

    • Kirsten L. Bryant
    • , Clint A. Stalnecker
    • , Daniel Zeitouni
    • , Jennifer E. Klomp
    • , Sen Peng
    • , Andrey P. Tikunov
    • , Venugopal Gunda
    • , Mariaelena Pierobon
    • , Andrew M. Waters
    • , Samuel D. George
    • , Garima Tomar
    • , Björn Papke
    • , G. Aaron Hobbs
    • , Liang Yan
    • , Tikvah K. Hayes
    • , J. Nathaniel Diehl
    • , Gennifer D. Goode
    • , Nina V. Chaika
    • , Yingxue Wang
    • , Guo-Fang Zhang
    • , Agnieszka K. Witkiewicz
    • , Erik S. Knudsen
    • , Emanuel F. Petricoin III
    • , Pankaj K. Singh
    • , Jeffrey M. Macdonald
    • , Nhan L. Tran
    • , Costas A. Lyssiotis
    • , Haoqiang Ying
    • , Alec C. Kimmelman
    • , Adrienne D. Cox
    •  & Channing J. Der
  • Article |

    Blockade of sialic acid-binding protein Siglec-15 expressed in cancer and tumor-infiltrating myeloid cells reverses immunesupression and represents a novel target for cancer immunotherapy independent from the PD-1/PD-L1 axis.

    • Jun Wang
    • , Jingwei Sun
    • , Linda N. Liu
    • , Dallas B. Flies
    • , Xinxin Nie
    • , Maria Toki
    • , Jianping Zhang
    • , Chang Song
    • , Melissa Zarr
    • , Xu Zhou
    • , Xue Han
    • , Kristina A. Archer
    • , Thomas O’Neill
    • , Roy S. Herbst
    • , Agedi N. Boto
    • , Miguel F. Sanmamed
    • , Solomon Langermann
    • , David L. Rimm
    •  & Lieping Chen
  • Article |

    Neoadjuvant pembrolizumab promotes a survival benefit with intratumoral and systemic immune responses in patients with recurrent glioblastoma.

    • Timothy F. Cloughesy
    • , Aaron Y. Mochizuki
    • , Joey R. Orpilla
    • , Willy Hugo
    • , Alexander H. Lee
    • , Tom B. Davidson
    • , Anthony C. Wang
    • , Benjamin M. Ellingson
    • , Julie A. Rytlewski
    • , Catherine M. Sanders
    • , Eric S. Kawaguchi
    • , Lin Du
    • , Gang Li
    • , William H. Yong
    • , Sarah C. Gaffey
    • , Adam L. Cohen
    • , Ingo K. Mellinghoff
    • , Eudocia Q. Lee
    • , David A. Reardon
    • , Barbara J. O’Brien
    • , Nicholas A. Butowski
    • , Phioanh L. Nghiemphu
    • , Jennifer L. Clarke
    • , Isabel C. Arrillaga-Romany
    • , Howard Colman
    • , Thomas J. Kaley
    • , John F. de Groot
    • , Linda M. Liau
    • , Patrick Y. Wen
    •  & Robert M. Prins
  • Article |

    ApoE is a direct checkpoint inhibitor of unresolvable inflammation in neurodegenerative and cardiovascular diseases

    • Changjun Yin
    • , Susanne Ackermann
    • , Zhe Ma
    • , Sarajo K. Mohanta
    • , Chuankai Zhang
    • , Yuanfang Li
    • , Sandor Nietzsche
    • , Martin Westermann
    • , Li Peng
    • , Desheng Hu
    • , Sai Vineela Bontha
    • , Prasad Srikakulapu
    • , Michael Beer
    • , Remco T. A. Megens
    • , Sabine Steffens
    • , Markus Hildner
    • , Luke D. Halder
    • , Hans-Henning Eckstein
    • , Jaroslav Pelisek
    • , Jochen Herms
    • , Sigrun Roeber
    • , Thomas Arzberger
    • , Anna Borodovsky
    • , Livia Habenicht
    • , Christoph J. Binder
    • , Christian Weber
    • , Peter F. Zipfel
    • , Christine Skerka
    •  & Andreas J. R. Habenicht
  • Article |

    A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

    • Bahtiyar Yilmaz
    • , Pascal Juillerat
    • , Ove Øyås
    • , Charlotte Ramon
    • , Francisco Damian Bravo
    • , Yannick Franc
    • , Nicolas Fournier
    • , Pierre Michetti
    • , Christoph Mueller
    • , Markus Geuking
    • , Valerie E. H. Pittet
    • , Michel H. Maillard
    • , Gerhard Rogler
    • , Karim Abdelrahman
    • , Gentiana Ademi
    • , Patrick Aepli
    • , Amman Thomas
    • , Claudia Anderegg
    • , Anca-Teodora Antonino
    • , Eva Archanioti
    • , Eviano Arrigoni
    • , Diana Bakker de Jong
    • , Bruno Balsiger
    • , Polat Bastürk
    • , Peter Bauerfeind
    • , Andrea Becocci
    • , Dominique Belli
    • , José M. Bengoa
    • , Luc Biedermann
    • , Janek Binek
    • , Mirjam Blattmann
    • , Stephan Boehm
    • , Tujana Boldanova
    • , Jan Borovicka
    • , Christian P. Braegger
    • , Stephan Brand
    • , Lukas Brügger
    • , Simon Brunner
    • , Patrick Bühr
    • , Bernard Burnand
    • , Sabine Burk
    • , Emanuel Burri
    • , Sophie Buyse
    • , Dahlia-Thao Cao
    • , Ove Carstens
    • , Dominique H. Criblez
    • , Sophie Cunningham
    • , Fabrizia D’Angelo
    • , Philippe de Saussure
    • , Lukas Degen
    • , Joakim Delarive
    • , Christopher Doerig
    • , Barbara Dora
    • , Susan Drerup
    • , Mara Egger
    • , Ali El-Wafa
    • , Matthias Engelmann
    • , Jessica Ezri
    • , Christian Felley
    • , Markus Fliegner
    • , Nicolas Fournier
    • , Montserrat Fraga
    • , Yannick Franc
    • , Pascal Frei
    • , Remus Frei
    • , Michael Fried
    • , Florian Froehlich
    • , Raoul Ivano Furlano
    • , Luca Garzoni
    • , Martin Geyer
    • , Laurent Girard
    • , Marc Girardin
    • , Delphine Golay
    • , Ignaz Good
    • , Ulrike Graf Bigler
    • , Beat Gysi
    • , Johannes Haarer
    • , Marcel Halama
    • , Janine Haldemann
    • , Pius Heer
    • , Benjamin Heimgartner
    • , Beat Helbling
    • , Peter Hengstler
    • , Denise Herzog
    • , Cyrill Hess
    • , Roxane Hessler
    • , Klaas Heyland
    • , Thomas Hinterleitner
    • , Claudia Hirschi
    • , Petr Hruz
    • , Pascal Juillerat
    • , Carolina Khalid-de Bakker
    • , Stephan Kayser
    • , Céline Keller
    • , Christina Knellwolf (-Grieger)
    • , Christoph Knoblauch
    • , Henrik Köhler
    • , Rebekka Koller
    • , Claudia Krieger(-Grübel)
    • , Patrizia Künzler
    • , Rachel Kusche
    • , Frank Serge Lehmann
    • , Andrew J. Macpherson
    • , Michel H. Maillard
    • , Michael Manz
    • , Astrid Marot
    • , Rémy Meier
    • , Christa Meyenberger
    • , Pamela Meyer
    • , Pierre Michetti
    • , Benjamin Misselwitz
    • , Patrick Mosler
    • , Christian Mottet
    • , Christoph Müller
    • , Beat Müllhaupt
    • , Leilla Musso
    • , Michaela Neagu
    • , Cristina Nichita
    • , Jan Niess
    • , Andreas Nydegger
    • , Nicole Obialo
    • , Diana Ollo
    • , Cassandra Oropesa
    • , Ulrich Peter
    • , Daniel Peternac
    • , Laetitia Marie Petit
    • , Valérie Pittet
    • , Daniel Pohl
    • , Marc Porzner
    • , Claudia Preissler
    • , Nadia Raschle
    • , Ronald Rentsch
    • , Alexandre Restellini
    • , Sophie Restellini
    • , Jean-Pierre Richterich
    • , Frederic Ris
    • , Branislav Risti
    • , Marc Alain Ritz
    • , Gerhard Rogler
    • , Nina Röhrich
    • , Jean-Benoît Rossel
    • , Vanessa Rueger
    • , Monica Rusticeanu
    • , Markus Sagmeister
    • , Gaby Saner
    • , Bernhard Sauter
    • , Mikael Sawatzki
    • , Michael Scharl
    • , Martin Schelling
    • , Susanne Schibli
    • , Hugo Schlauri
    • , Dominique Schluckebier
    • , Daniela Schmid
    • , Sybille Schmid (-Uebelhart)
    • , Jean-François Schnegg
    • , Alain Schoepfer
    • , Vivianne Seematter
    • , Frank Seibold
    • , Mariam Seirafi
    • , Gian-Marco Semadeni
    • , Arne Senning
    • , Christiane Sokollik
    • , Joachim Sommer
    • , Johannes Spalinger
    • , Holger Spangenberger
    • , Philippe Stadler
    • , Peter Staub
    • , Dominic Staudenmann
    • , Volker Stenz
    • , Michael Steuerwald
    • , Alex Straumann
    • , Bruno Strebel
    • , Andreas Stulz
    • , Michael Sulz
    • , Aurora Tatu
    • , Michela Tempia-Caliera
    • , Joël Thorens
    • , Kaspar Truninger
    • , Radu Tutuian
    • , Patrick Urfer
    • , Stephan Vavricka
    • , Francesco Viani
    • , Jürg Vögtlin
    • , Roland Von Känel
    • , Dominique Vouillamoz
    • , Rachel Vulliamy
    • , Paul Wiesel
    • , Reiner Wiest
    • , Stefanie Wöhrle
    • , Samuel Zamora
    • , Silvan Zander
    • , Tina Wylie
    • , Jonas Zeitz
    • , Dorothee Zimmermann
    • , Reiner Wiest
    • , Jörg Stelling
    •  & Andrew J. Macpherson
  • Article |

    Oncogene cooperation enhances PD-L1 translation to promote immune evasion and metastasis in a novel model of liver cancer.

    • Yichen Xu
    • , Mauro Poggio
    • , Hyun Yong Jin
    • , Zhen Shi
    • , Craig M. Forester
    • , Ying Wang
    • , Craig R. Stumpf
    • , Lingru Xue
    • , Emily Devericks
    • , Lomon So
    • , Hao G. Nguyen
    • , Alice Griselin
    • , John D. Gordan
    • , Sarah E Umetsu
    • , Siegfried H. Reich
    • , Stephen T. Worland
    • , Saurabh Asthana
    • , Maria Barna
    • , Kevin R. Webster
    • , John T. Cunningham
    •  & Davide Ruggero
  • Article |

    Expression of the exercise-induced myokine irisin (FNDC5) is lower in patients with AD. Whereas knockdown of FNDC5/irisin is sufficient to induce learning and memory deficits, restoration of its expression can ameliorate these phenotypes in rodent models.

    • Mychael V. Lourenco
    • , Rudimar L. Frozza
    • , Guilherme B. de Freitas
    • , Hong Zhang
    • , Grasielle C. Kincheski
    • , Felipe C. Ribeiro
    • , Rafaella A. Gonçalves
    • , Julia R. Clarke
    • , Danielle Beckman
    • , Agnieszka Staniszewski
    • , Hanna Berman
    • , Lorena A. Guerra
    • , Letícia Forny-Germano
    • , Shelby Meier
    • , Donna M. Wilcock
    • , Jorge M. de Souza
    • , Soniza Alves-Leon
    • , Vania F. Prado
    • , Marco A. M. Prado
    • , Jose F. Abisambra
    • , Fernanda Tovar-Moll
    • , Paulo Mattos
    • , Ottavio Arancio
    • , Sergio T. Ferreira
    •  & Fernanda G. De Felice
  • Article |

    Single cell dissection of plasma cell heterogeneity in myeloma patients reveals new insights into disease that may inform early diagnosis and clinical management.

    • Guy Ledergor
    • , Assaf Weiner
    • , Mor Zada
    • , Shuang-Yin Wang
    • , Yael C. Cohen
    • , Moshe E. Gatt
    • , Nimrod Snir
    • , Hila Magen
    • , Maya Koren-Michowitz
    • , Katrin Herzog-Tzarfati
    • , Hadas Keren-Shaul
    • , Chamutal Bornstein
    • , Ron Rotkopf
    • , Ido Yofe
    • , Eyal David
    • , Venkata Yellapantula
    • , Sigalit Kay
    • , Moshe Salai
    • , Dina Ben Yehuda
    • , Arnon Nagler
    • , Lev Shvidel
    • , Avi Orr-Urtreger
    • , Keren Bahar Halpern
    • , Shalev Itzkovitz
    • , Ola Landgren
    • , Jesus San-Miguel
    • , Bruno Paiva
    • , Jonathan J. Keats
    • , Elli Papaemmanuil
    • , Irit Avivi
    • , Gabriel I. Barbash
    • , Amos Tanay
    •  & Ido Amit
  • Article |

    Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

    • Vivek Swarup
    • , Flora I. Hinz
    • , Jessica E. Rexach
    • , Ken-ichi Noguchi
    • , Hiroyoshi Toyoshiba
    • , Akira Oda
    • , Keisuke Hirai
    • , Arjun Sarkar
    • , Nicholas T. Seyfried
    • , Chialin Cheng
    • , Stephen J. Haggarty
    • , Raffaele Ferrari
    • , Jonathan D. Rohrer
    • , Adaikalavan Ramasamy
    • , John Hardy
    • , Dena G. Hernandez
    • , Michael A. Nalls
    • , Andrew B. Singleton
    • , John B. J. Kwok
    • , Carol Dobson-Stone
    • , William S. Brooks
    • , Peter R. Schofield
    • , Glenda M. Halliday
    • , John R. Hodges
    • , Olivier Piguet
    • , Lauren Bartley
    • , Elizabeth Thompson
    • , Eric Haan
    • , Isabel Hernández
    • , Agustín Ruiz
    • , Mercè Boada
    • , Barbara Borroni
    • , Alessandro Padovani
    • , Nigel J. Cairns
    • , Carlos Cruchaga
    • , Giuliano Binetti
    • , Roberta Ghidoni
    • , Luisa Benussi
    • , Gianluigi Forloni
    • , Diego Albani
    • , Daniela Galimberti
    • , Chiara Fenoglio
    • , Maria Serpente
    • , Elio Scarpini
    • , Jordi Clarimón
    • , Alberto Lleó
    • , Rafael Blesa
    • , Maria Landqvist Waldö
    • , Karin Nilsson
    • , Christer Nilsson
    • , Ian R. A. Mackenzie
    • , Ging-Yuek R. Hsiung
    • , David M. A. Mann
    • , Jordan Grafman
    • , Christopher M. Morris
    • , Johannes Attems
    • , Timothy D. Griffiths
    • , Ian G. McKeith
    • , Alan J. Thomas
    • , Evelyn Jaros
    • , Pietro Pietrini
    • , Edward D. Huey
    • , Eric M. Wassermann
    • , Michael C. Tierney
    • , Atik Baborie
    • , Pau Pastor
    • , Sara Ortega-Cubero
    • , Cristina Razquin
    • , Elena Alonso
    • , Robert Perneczky
    • , Janine Diehl-Schmid
    • , Panagiotis Alexopoulos
    • , Alexander Kurz
    • , Innocenzo Rainero
    • , Elisa Rubino
    • , Lorenzo Pinessi
    • , Ekaterina Rogaeva
    • , Peter St. George-Hyslop
    • , Giacomina Rossi
    • , Fabrizio Tagliavini
    • , Giorgio Giaccone
    • , James B. Rowe
    • , Johannes C. M. Schlachetzki
    • , James Uphill
    • , John Collinge
    • , Simon Mead
    • , Adrian Danek
    • , Vivianna M. Van Deerlin
    • , Murray Grossman
    • , John Q. Trojanowski
    • , Stuart Pickering-Brown
    • , Parastoo Momeni
    • , Julie van der Zee
    • , Marc Cruts
    • , Christine Van Broeckhoven
    • , Stefano F. Cappa
    • , Isabelle Leber
    • , Alexis Brice
    • , Didier Hannequin
    • , Véronique Golfier
    • , Martine Vercelletto
    • , Benedetta Nacmias
    • , Sandro Sorbi
    • , Silvia Bagnoli
    • , Irene Piaceri
    • , Jørgen E. Nielsen
    • , Lena E. Hjermind
    • , Matthias Riemenschneider
    • , Manuel Mayhaus
    • , Gilles Gasparoni
    • , Sabrina Pichler
    • , Bernd Ibach
    • , Martin N. Rossor
    • , Nick C. Fox
    • , Jason D. Warren
    • , Maria Grazia Spillantini
    • , Huw R. Morris
    • , Patrizia Rizzu
    • , Peter Heutink
    • , Julie S. Snowden
    • , Sara Rollinson
    • , Alexander Gerhard
    • , Anna Richardson
    • , Amalia C. Bruni
    • , Raffaele Maletta
    • , Francesca Frangipane
    • , Chiara Cupidi
    • , Livia Bernardi
    • , Maria Anfossi
    • , Maura Gallo
    • , Maria Elena Conidi
    • , Nicoletta Smirne
    • , Rosa Rademakers
    • , Matt Baker
    • , Dennis W. Dickson
    • , Neill R. Graff-Radford
    • , Ronald C. Petersen
    • , David Knopman
    • , Keith A. Josephs
    • , Bradley F. Boeve
    • , Joseph E. Parisi
    • , Bruce L. Miller
    • , Anna M. Karydas
    • , Howard Rosen
    • , William W. Seeley
    • , John C. van Swieten
    • , Elise G. P. Dopper
    • , Harro Seelaar
    • , Yolande A. L. Pijnenburg
    • , Philip Scheltens
    • , Giancarlo Logroscino
    • , Rosa Capozzo
    • , Valeria Novelli
    • , Annibale A. Puca
    • , Massimo Franceschi
    • , Alfredo Postiglione
    • , Graziella Milan
    • , Paolo Sorrentino
    • , Mark Kristiansen
    • , Huei-Hsin Chiang
    • , Caroline Graff
    • , Florence Pasquier
    • , Adeline Rollin
    • , Vincent Deramecourt
    • , Thibaud Lebouvier
    • , Luigi Ferrucci
    • , Dimitrios Kapogiannis
    • , Murray Grossman
    • , Vivianna M. Van Deerlin
    • , John Q. Trojanowski
    • , James J. Lah
    • , Allan I. Levey
    • , Shinichi Kondou
    •  & Daniel H. Geschwind
  • Article |

    WASP is a novel tumor-suppressor gene in ALK-driven anaplastic large cell lymphoma through modulation of CDC42 and MAPK signaling and provides a rationale for combination therapy.

    • Matteo Menotti
    • , Chiara Ambrogio
    • , Taek-Chin Cheong
    • , Chiara Pighi
    • , Ines Mota
    • , Seth H. Cassel
    • , Mara Compagno
    • , Qi Wang
    • , Riccardo Dall’Olio
    • , Valerio G. Minero
    • , Teresa Poggio
    • , Geeta Geeta Sharma
    • , Enrico Patrucco
    • , Cristina Mastini
    • , Ramesh Choudhari
    • , Achille Pich
    • , Alberto Zamo
    • , Roberto Piva
    • , Silvia Giliani
    • , Luca Mologni
    • , Clayton K. Collings
    • , Cigall Kadoch
    • , Carlo Gambacorti-Passerini
    • , Luigi D. Notarangelo
    • , Ines M. Anton
    • , Claudia Voena
    •  & Roberto Chiarle
  • Article |

    ONECUT2 is a targetable transcription factor that antagonizes androgen receptor signaling and drives androgen independence and neuroendocrine differentiation in castration-resistant prostate cancer.

    • Mirja Rotinen
    • , Sungyong You
    • , Julie Yang
    • , Simon G. Coetzee
    • , Mariana Reis-Sobreiro
    • , Wen-Chin Huang
    • , Fangjin Huang
    • , Xinlei Pan
    • , Alberto Yáñez
    • , Dennis J. Hazelett
    • , Chia-Yi Chu
    • , Kenneth Steadman
    • , Colm M. Morrissey
    • , Peter S. Nelson
    • , Eva Corey
    • , Leland W. K. Chung
    • , Stephen J. Freedland
    • , Dolores Di Vizio
    • , Isla P. Garraway
    • , Ramachandran Murali
    • , Beatrice S. Knudsen
    •  & Michael R. Freeman
  • Article |

    Molecular alterations in ctDNA of patients with mantle cell lymphoma uncovers mutations in SWI–SNF associated with resistance to ibrutinib and venetoclax combination and provide a rationale for restoring sensitivity through Bcl-xL inhibition.

    • Rishu Agarwal
    • , Yih-Chih Chan
    • , Constantine S. Tam
    • , Tane Hunter
    • , Dane Vassiliadis
    • , Charis E. Teh
    • , Rachel Thijssen
    • , Paul Yeh
    • , Stephen Q. Wong
    • , Sarah Ftouni
    • , Enid Y. N. Lam
    • , Mary Ann Anderson
    • , Christiane Pott
    • , Omer Gilan
    • , Charles C. Bell
    • , Kathy Knezevic
    • , Piers Blombery
    • , Kathleen Rayeroux
    • , Adrian Zordan
    • , Jason Li
    • , David C. S. Huang
    • , Meaghan Wall
    • , John F. Seymour
    • , Daniel H. D. Gray
    • , Andrew W. Roberts
    • , Mark A. Dawson
    •  & Sarah-Jane Dawson
  • Article |

    Targeting of mitochondrial metabolism in combination with BCL-2 inhibition eradicates leukemia stem cells and induces long-lasting responses in patients with acute myeloid leukemia.

    • Daniel A. Pollyea
    • , Brett M. Stevens
    • , Courtney L. Jones
    • , Amanda Winters
    • , Shanshan Pei
    • , Mohammad Minhajuddin
    • , Angelo D’Alessandro
    • , Rachel Culp-Hill
    • , Kent A. Riemondy
    • , Austin E. Gillen
    • , Jay R. Hesselberth
    • , Diana Abbott
    • , Derek Schatz
    • , Jonathan A. Gutman
    • , Enkhtsetseg Purev
    • , Clayton Smith
    •  & Craig T. Jordan
  • Article |

    Obesity promotes tumor growth yet simultaneously increases susceptibility to PD-1-targeted cancer immunotherapy.

    • Ziming Wang
    • , Ethan G. Aguilar
    • , Jesus I. Luna
    • , Cordelia Dunai
    • , Lam T. Khuat
    • , Catherine T. Le
    • , Annie Mirsoian
    • , Christine M. Minnar
    • , Kevin M. Stoffel
    • , Ian R. Sturgill
    • , Steven K. Grossenbacher
    • , Sita S. Withers
    • , Robert B. Rebhun
    • , Dennis J. Hartigan-O’Connor
    • , Gema Méndez-Lagares
    • , Alice F. Tarantal
    • , R. Rivkah Isseroff
    • , Thomas S. Griffith
    • , Kurt A. Schalper
    • , Alexander Merleev
    • , Asim Saha
    • , Emanual Maverakis
    • , Karen Kelly
    • , Raid Aljumaily
    • , Sami Ibrahimi
    • , Sarbajit Mukherjee
    • , Michael Machiorlatti
    • , Sara K. Vesely
    • , Dan L. Longo
    • , Bruce R. Blazar
    • , Robert J. Canter
    • , William J. Murphy
    •  & Arta M. Monjazeb
  • Article |

    A novel orphan noncoding RNA species with tumor-specific expression across breast cancer subtypes promotes metastatic progression and holds potential for patient diagnosis.

    • Lisa Fish
    • , Steven Zhang
    • , Johnny X. Yu
    • , Bruce Culbertson
    • , Alicia Y. Zhou
    • , Andrei Goga
    •  & Hani Goodarzi
  • Article
    | Open Access

    Analysis of tuberculosis drug trials identifies features to stratify patients for longer or shorter treatment duration than the standard of care, in order to improve therapeutic outcomes.

    • Marjorie Z. Imperial
    • , Payam Nahid
    • , Patrick P. J. Phillips
    • , Geraint R. Davies
    • , Katherine Fielding
    • , Debra Hanna
    • , David Hermann
    • , Robert S. Wallis
    • , John L. Johnson
    • , Christian Lienhardt
    •  & Rada M. Savic
  • Article |

    Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

    • Lulu Sun
    • , Cen Xie
    • , Guang Wang
    • , Yue Wu
    • , Qing Wu
    • , Xuemei Wang
    • , Jia Liu
    • , Yangyang Deng
    • , Jialin Xia
    • , Bo Chen
    • , Songyang Zhang
    • , Chuyu Yun
    • , Guan Lian
    • , Xiujuan Zhang
    • , Heng Zhang
    • , William H. Bisson
    • , Jingmin Shi
    • , Xiaoxia Gao
    • , Pupu Ge
    • , Cuihua Liu
    • , Kristopher W. Krausz
    • , Robert G. Nichols
    • , Jingwei Cai
    • , Bipin Rimal
    • , Andrew D. Patterson
    • , Xian Wang
    • , Frank J. Gonzalez
    •  & Changtao Jiang
  • Article |

    The translation initiation complex mediates tumor immune escape in melanoma by controlling STAT1 mRNA levels and T lymphocyte–induced PD-L1 expression.

    • Michaël Cerezo
    • , Ramdane Guemiri
    • , Sabine Druillennec
    • , Isabelle Girault
    • , Hélène Malka-Mahieu
    • , Shensi Shen
    • , Delphine Allard
    • , Sylvain Martineau
    • , Caroline Welsch
    • , Sandrine Agoussi
    • , Charlène Estrada
    • , Julien Adam
    • , Cristina Libenciuc
    • , Emilie Routier
    • , Séverine Roy
    • , Laurent Désaubry
    • , Alexander M. Eggermont
    • , Nahum Sonenberg
    • , Jean Yves Scoazec
    • , Alain Eychène
    • , Stéphan Vagner
    •  & Caroline Robert
  • Article |

    Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

    • Jorge Sepulcre
    • , Michel J. Grothe
    • , Federico d’Oleire Uquillas
    • , Laura Ortiz-Terán
    • , Ibai Diez
    • , Hyun-Sik Yang
    • , Heidi I. L. Jacobs
    • , Bernard J. Hanseeuw
    • , Quanzheng Li
    • , Georges El-Fakhri
    • , Reisa A. Sperling
    •  & Keith A. Johnson
  • Article |

    Targeting different aspects of mutant CFTR structural defects with combination therapy leads to more potent rescue of function than that following single therapy.

    • Guido Veit
    • , Haijin Xu
    • , Elise Dreano
    • , Radu G. Avramescu
    • , Miklos Bagdany
    • , Lenore K. Beitel
    • , Ariel Roldan
    • , Mark A. Hancock
    • , Cecilia Lay
    • , Wei Li
    • , Katelin Morin
    • , Sandra Gao
    • , Puiying A. Mak
    • , Edward Ainscow
    • , Anthony P. Orth
    • , Peter McNamara
    • , Aleksander Edelman
    • , Saul Frenkiel
    • , Elias Matouk
    • , Isabelle Sermet-Gaudelus
    • , William G. Barnes
    •  & Gergely L. Lukacs
  • Article |

    Systemic administration of human PBGD mRNA encapsulated in lipid nanoparticles ameliorates disease phenotypes in mouse and rabbit models of acute hepatic porphyria and is safe in nonhuman primates.

    • Lei Jiang
    • , Pedro Berraondo
    • , Daniel Jericó
    • , Lin T. Guey
    • , Ana Sampedro
    • , Andrea Frassetto
    • , Kerry E. Benenato
    • , Kristine Burke
    • , Eva Santamaría
    • , Manuel Alegre
    • , Álvaro Pejenaute
    • , Mayur Kalariya
    • , William Butcher
    • , Ji-Sun Park
    • , Xuling Zhu
    • , Staci Sabnis
    • , E. Sathyajith Kumarasinghe
    • , Timothy Salerno
    • , Matthew Kenney
    • , Christine M. Lukacs
    • , Matías A. Ávila
    • , Paolo G. V. Martini
    •  & Antonio Fontanellas
  • Article |

    Kidney compartment–specific eQTL analysis goes beyond GWAS to reveal causal genes and pathways involved in renal disease development.

    • Chengxiang Qiu
    • , Shizheng Huang
    • , Jihwan Park
    • , YoSon Park
    • , Yi-An Ko
    • , Matthew J. Seasock
    • , Joshua S. Bryer
    • , Xiang-Xi Xu
    • , Wen-Chao Song
    • , Matthew Palmer
    • , Jon Hill
    • , Paolo Guarnieri
    • , Julie Hawkins
    • , Carine M. Boustany-Kari
    • , Steven S. Pullen
    • , Christopher D. Brown
    •  & Katalin Susztak
  • Article |

    Interdependence between YAP/TAZ and BRD4 drives transcriptional addiction in cancer cells and determines sensitivity to BET inhibition.

    • Francesca Zanconato
    • , Giusy Battilana
    • , Mattia Forcato
    • , Letizia Filippi
    • , Luca Azzolin
    • , Andrea Manfrin
    • , Erika Quaranta
    • , Daniele Di Biagio
    • , Gianluca Sigismondo
    • , Vincenza Guzzardo
    • , Pascale Lejeune
    • , Bernard Haendler
    • , Jeroen Krijgsveld
    • , Matteo Fassan
    • , Silvio Bicciato
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo
  • Article |

    A convolutional neural network model using feature extraction and machine-learning techniques provides a tool for classification of lung cancer histopathology images and predicting mutational status of driver oncogenes

    • Nicolas Coudray
    • , Paolo Santiago Ocampo
    • , Theodore Sakellaropoulos
    • , Navneet Narula
    • , Matija Snuderl
    • , David Fenyö
    • , Andre L. Moreira
    • , Narges Razavian
    •  & Aristotelis Tsirigos
  • Article |

    Distinct routes of immunization elicit different antibody isotypes and functions associated with protection against SIV infection that converge on phagocytosis as a candidate protective mechanism of independent SIV vaccines.

    • Margaret E. Ackerman
    • , Jishnu Das
    • , Srivamshi Pittala
    • , Thomas Broge
    • , Caitlyn Linde
    • , Todd J. Suscovich
    • , Eric P. Brown
    • , Todd Bradley
    • , Harini Natarajan
    • , Shu Lin
    • , Jessica K. Sassic
    • , Sean O’Keefe
    • , Nickita Mehta
    • , Derrick Goodman
    • , Magdalena Sips
    • , Joshua A. Weiner
    • , Georgia D. Tomaras
    • , Barton F. Haynes
    • , Douglas A. Lauffenburger
    • , Chris Bailey-Kellogg
    • , Mario Roederer
    •  & Galit Alter
  • Article |

    The antidiabetic action of metformin raises heptocyte intracellular AMP levels, causing allosteric inhibition of fructose-1,6-bisphosphatase and thus reductions in gluconeogenesis.

    • Roger W. Hunter
    • , Curtis C. Hughey
    • , Louise Lantier
    • , Elias I. Sundelin
    • , Mark Peggie
    • , Elton Zeqiraj
    • , Frank Sicheri
    • , Niels Jessen
    • , David H. Wasserman
    •  & Kei Sakamoto
  • Article |

    Impaired NAD+ biosynthesis may be a common feature of high-risk hospitalizations for which NAD+ augmentation could improve therapeutic outcome.

    • Ali Poyan Mehr
    • , Mei T. Tran
    • , Kenneth M. Ralto
    • , David E. Leaf
    • , Vaughan Washco
    • , Joseph Messmer
    • , Adam Lerner
    • , Ajay Kher
    • , Steven H. Kim
    • , Charbel C. Khoury
    • , Shoshana J. Herzig
    • , Mary E. Trovato
    • , Noemie Simon-Tillaux
    • , Matthew R. Lynch
    • , Ravi I. Thadhani
    • , Clary B. Clish
    • , Kamal R. Khabbaz
    • , Eugene P. Rhee
    • , Sushrut S. Waikar
    • , Anders H. Berg
    •  & Samir M. Parikh
  • Article |

    iPSC-derived motor neurons from over 30 heterogeneous sporadic ALS cases exhibit pathologies correlated with clinical disease progression, are more similar to FUS/TDP-43 familial ALS than SOD1-ALS and are corrected by repurposing of ropinirole.

    • Koki Fujimori
    • , Mitsuru Ishikawa
    • , Asako Otomo
    • , Naoki Atsuta
    • , Ryoichi Nakamura
    • , Tetsuya Akiyama
    • , Shinji Hadano
    • , Masashi Aoki
    • , Hideyuki Saya
    • , Gen Sobue
    •  & Hideyuki Okano
  • Article |

    An algorithm-selected gene signature focused on tumor immune evasion and suppression predicts response to immune checkpoint blockade in melanoma, exceeding the accuracy of current clinical biomarkers.

    • Peng Jiang
    • , Shengqing Gu
    • , Deng Pan
    • , Jingxin Fu
    • , Avinash Sahu
    • , Xihao Hu
    • , Ziyi Li
    • , Nicole Traugh
    • , Xia Bu
    • , Bo Li
    • , Jun Liu
    • , Gordon J. Freeman
    • , Myles A. Brown
    • , Kai W. Wucherpfennig
    •  & X. Shirley Liu
  • Article |

    CRISPR–Cas9-mediated gene editing of TSC1 and TSC2 in human pluripotent stem cells is used to investigate the contribution of tuberous sclerosis complex–mechanistic target of rapamycin complex 1 signaling to human neural development in two-dimensional monolayer and three-dimensional spheroid models of the neurodevelopmental disorder tuberous sclerosis complex.

    • John D. Blair
    • , Dirk Hockemeyer
    •  & Helen S. Bateup
  • Article |

    Patients with glioblastoma experience lymphopenia and sequestration of T cells in the bone marrow, which is recapitulated in mice with brain tumors, where the reversible nature of this effect is demonstrated by an approach that enables the efficacy of other immunotherapeutics.

    • Pakawat Chongsathidkiet
    • , Christina Jackson
    • , Shohei Koyama
    • , Franziska Loebel
    • , Xiuyu Cui
    • , S. Harrison Farber
    • , Karolina Woroniecka
    • , Aladine A. Elsamadicy
    • , Cosette A. Dechant
    • , Hanna R. Kemeny
    • , Luis Sanchez-Perez
    • , Tooba A. Cheema
    • , Nicholas C. Souders
    • , James E. Herndon
    • , Jean-Valery Coumans
    • , Jeffrey I. Everitt
    • , Brian V. Nahed
    • , John H. Sampson
    • , Michael D. Gunn
    • , Robert L. Martuza
    • , Glenn Dranoff
    • , William T. Curry
    •  & Peter E. Fecci
  • Article |

    A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.

    • Jeffrey De Fauw
    • , Joseph R. Ledsam
    • , Bernardino Romera-Paredes
    • , Stanislav Nikolov
    • , Nenad Tomasev
    • , Sam Blackwell
    • , Harry Askham
    • , Xavier Glorot
    • , Brendan O’Donoghue
    • , Daniel Visentin
    • , George van den Driessche
    • , Balaji Lakshminarayanan
    • , Clemens Meyer
    • , Faith Mackinder
    • , Simon Bouton
    • , Kareem Ayoub
    • , Reena Chopra
    • , Dominic King
    • , Alan Karthikesalingam
    • , Cían O. Hughes
    • , Rosalind Raine
    • , Julian Hughes
    • , Dawn A. Sim
    • , Catherine Egan
    • , Adnan Tufail
    • , Hugh Montgomery
    • , Demis Hassabis
    • , Geraint Rees
    • , Trevor Back
    • , Peng T. Khaw
    • , Mustafa Suleyman
    • , Julien Cornebise
    • , Pearse A. Keane
    •  & Olaf Ronneberger
  • Article |

    A blood-based DNA sequencing assay to infer tumor mutational burden in the absence of tumor biopsy predicts response to PD-L1 blockade in patients with non-small-cell lung cancer.

    • David R. Gandara
    • , Sarah M. Paul
    • , Marcin Kowanetz
    • , Erica Schleifman
    • , Wei Zou
    • , Yan Li
    • , Achim Rittmeyer
    • , Louis Fehrenbacher
    • , Geoff Otto
    • , Christine Malboeuf
    • , Daniel S. Lieber
    • , Doron Lipson
    • , Jacob Silterra
    • , Lukas Amler
    • , Todd Riehl
    • , Craig A. Cummings
    • , Priti S. Hegde
    • , Alan Sandler
    • , Marcus Ballinger
    • , David Fabrizio
    • , Tony Mok
    •  & David S. Shames
  • Article |

    A bacterial screen yields a Cas9 variant that retains high on-target activity when delivered in the RNP format. As proof of principle, this Cas9 variant enables high-level correction of the sickle cell disease mutation in patient-derived HSPCs.

    • Christopher A. Vakulskas
    • , Daniel P. Dever
    • , Garrett R. Rettig
    • , Rolf Turk
    • , Ashley M. Jacobi
    • , Michael A. Collingwood
    • , Nicole M. Bode
    • , Matthew S. McNeill
    • , Shuqi Yan
    • , Joab Camarena
    • , Ciaran M. Lee
    • , So Hyun Park
    • , Volker Wiebking
    • , Rasmus O. Bak
    • , Natalia Gomez-Ospina
    • , Mara Pavel-Dinu
    • , Wenchao Sun
    • , Gang Bao
    • , Matthew H. Porteus
    •  & Mark A. Behlke
  • Article |

    Mechanism-based small-molecule inhibitors targeting a gut microbial enzyme lower circulating levels of the prothrombotic metabolite trimethylamine-N-oxide and suppress diet-induced thrombosis in mice.

    • Adam B. Roberts
    • , Xiaodong Gu
    • , Jennifer A. Buffa
    • , Alex G. Hurd
    • , Zeneng Wang
    • , Weifei Zhu
    • , Nilaksh Gupta
    • , Sarah M. Skye
    • , David B. Cody
    • , Bruce S. Levison
    • , William T. Barrington
    • , Matthew W. Russell
    • , Jodie M. Reed
    • , Ashraf Duzan
    • , Jennifer M. Lang
    • , Xiaoming Fu
    • , Lin Li
    • , Alex J. Myers
    • , Suguna Rachakonda
    • , Joseph A. DiDonato
    • , J. Mark Brown
    • , Valentin Gogonea
    • , Aldons J. Lusis
    • , Jose Carlos Garcia-Garcia
    •  & Stanley L. Hazen
  • Article |

    Early and prolonged administration of antiretroviral therapy to SIV-infected and post-exposure-vaccinated rhesus macaques was associated with absence or delay of detectable virus after therapy interruption.

    • Afam A. Okoye
    • , Scott G. Hansen
    • , Mukta Vaidya
    • , Yoshinori Fukazawa
    • , Haesun Park
    • , Derick M. Duell
    • , Richard Lum
    • , Colette M. Hughes
    • , Abigail B. Ventura
    • , Emily Ainslie
    • , Julia C. Ford
    • , David Morrow
    • , Roxanne M. Gilbride
    • , Alfred W. Legasse
    • , Joseph Hesselgesser
    • , Romas Geleziunas
    • , Yuan Li
    • , Kelli Oswald
    • , Rebecca Shoemaker
    • , Randy Fast
    • , William J. Bosche
    • , Bhavesh R. Borate
    • , Paul T. Edlefsen
    • , Michael K. Axthelm
    • , Louis J. Picker
    •  & Jeffrey D. Lifson
  • Article |

    The muscle-secreted, exercise-induced peptide hormone apelin decreases with aging and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function.

    • Claire Vinel
    • , Laura Lukjanenko
    • , Aurelie Batut
    • , Simon Deleruyelle
    • , Jean-Philippe Pradère
    • , Sophie Le Gonidec
    • , Alizée Dortignac
    • , Nancy Geoffre
    • , Ophelie Pereira
    • , Sonia Karaz
    • , Umji Lee
    • , Mylène Camus
    • , Karima Chaoui
    • , Etienne Mouisel
    • , Anne Bigot
    • , Vincent Mouly
    • , Mathieu Vigneau
    • , Allan F. Pagano
    • , Angèle Chopard
    • , Fabien Pillard
    • , Sophie Guyonnet
    • , Matteo Cesari
    • , Odile Burlet-Schiltz
    • , Marco Pahor
    • , Jerome N. Feige
    • , Bruno Vellas
    • , Philippe Valet
    •  & Cedric Dray
  • Article |

    Oncogenic NOTCH1 controls transcriptional activation of the heat shock response in T cell acute lymphoblastic leukemia and uncovers potential biomarkers of sensitivity to HSP90 inhibition.

    • Nikos Kourtis
    • , Charalampos Lazaris
    • , Kathryn Hockemeyer
    • , Juan Carlos Balandrán
    • , Alejandra R. Jimenez
    • , Jasper Mullenders
    • , Yixiao Gong
    • , Thomas Trimarchi
    • , Kamala Bhatt
    • , Hai Hu
    • , Liza Shrestha
    • , Alberto Ambesi-Impiombato
    • , Michelle Kelliher
    • , Elisabeth Paietta
    • , Gabriela Chiosis
    • , Monica L. Guzman
    • , Adolfo A. Ferrando
    • , Aristotelis Tsirigos
    •  & Iannis Aifantis
  • Article |

    Interleukin-1β promotes an atheroprotective phenotype in late-stage lesions of mice, suggesting the possibility of deleterious effects of interleukin-1β blockade in the setting of myocardial infarction.

    • Delphine Gomez
    • , Richard A. Baylis
    • , Brittany G. Durgin
    • , Alexandra A. C. Newman
    • , Gabriel F. Alencar
    • , Sidney Mahan
    • , Cynthia St. Hilaire
    • , Werner Müller
    • , Ari Waisman
    • , Sheila E. Francis
    • , Emmanuel Pinteaux
    • , Gwendalyn J. Randolph
    • , Hermann Gram
    •  & Gary K. Owens
  • Article |

    Topographic analysis of the active regulatory landscape in estrogen receptor-positive breast cancer uncovers a role for transcription factor YY1 in modulating phenotypic heterogeneity during tumor evolution and endocrine resistance.

    • Darren K. Patten
    • , Giacomo Corleone
    • , Balázs Győrffy
    • , Ylenia Perone
    • , Neil Slaven
    • , Iros Barozzi
    • , Edina Erdős
    • , Alina Saiakhova
    • , Kate Goddard
    • , Andrea Vingiani
    • , Sami Shousha
    • , Lőrinc Sándor Pongor
    • , Dimitri J. Hadjiminas
    • , Gaia Schiavon
    • , Peter Barry
    • , Carlo Palmieri
    • , Raul C. Coombes
    • , Peter Scacheri
    • , Giancarlo Pruneri
    •  & Luca Magnani
  • Article |

    Using 13C-labeled substrates in vivo, this group shows that metformin inhibits mG3PDH to reduce hepatic gluconeogenesis and lower glycemia by altering the redox potential of the cytosol of hepatocytes rather than affecting substrate availability.

    • Anila K. Madiraju
    • , Yang Qiu
    • , Rachel J. Perry
    • , Yasmeen Rahimi
    • , Xian-Man Zhang
    • , Dongyan Zhang
    • , João-Paulo G. Camporez
    • , Gary W. Cline
    • , Gina M. Butrico
    • , Bruce E. Kemp
    • , Gregori Casals
    • , Gregory R. Steinberg
    • , Daniel F. Vatner
    • , Kitt F. Petersen
    •  & Gerald I. Shulman
  • Article |

    Microsatellite instability and Epstein–Barr virus positivity represent novel biomarkers of clinical response to PD-1 blockade in patients with metastatic gastric cancer.

    • Seung Tae Kim
    • , Razvan Cristescu
    • , Adam J. Bass
    • , Kyoung-Mee Kim
    • , Justin I. Odegaard
    • , Kyung Kim
    • , Xiao Qiao Liu
    • , Xinwei Sher
    • , Hun Jung
    • , Mijin Lee
    • , Sujin Lee
    • , Se Hoon Park
    • , Joon Oh Park
    • , Young Suk Park
    • , Ho Yeong Lim
    • , Hyuk Lee
    • , Mingew Choi
    • , AmirAli Talasaz
    • , Peter Soonmo Kang
    • , Jonathan Cheng
    • , Andrey Loboda
    • , Jeeyun Lee
    •  & Won Ki Kang