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It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)
Examination of the effects of three new drugs shows that the destruction of the immune system in AIDS reflects fulminant HIV production, which eventually overwhelms the immune system's prodigious powers of regeneration.
One of the most contentious issues facing the NIH this year will be deciding what types of human embryo research should receive federal funds. President Bill Clinton has already ruled out one whole area.
By careful microscopic examination of in vitro fertilization (pages 47–52) Simerly et al. demonstrate the paternal origin of the human centrosome and reveal steps at which fertilization may fail.
Two recent reports provide further evidence for a link between coxsackieviruses and the onset of IDDM, although a careful examination suggests it is still too early to conclude a definitive role.