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In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-peptide analogues

Nature Medicine volume 1, pages 138–142 (1995)Cite this article

Abstract

We have studied the effects of amyloid β-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears to increase when β-peptides form aggregated fibrillar structures similar to those found in amyloid deposits. This finding is significant in that it may provide insights into the pathogenesis of hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D) and cerebral amyloid angiopathy-related cerebral haemorrhage. It may also provide an explanation for the deaths resulting from intracerebral haemorrhage that have occurred in patients undergoing t-PA treatment for acute myocardial infarction.

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Authors and Affiliations

  1. Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey, 08854, USA

    I. Barry Kinston, Maria José M. Castro & Stephen Anderson

  2. Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK

    I. Barry Kinston

  3. Department of Microbiology, Rutgers University, New Brunswick, New Jersey, 08903, USA

    Maria José M. Castro

  4. Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, New Jersey, 08903, USA

    Stephen Anderson

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Kinston, I., Castro, M. & Anderson, S. In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-peptide analogues. Nat Med 1, 138–142 (1995). https://doi.org/10.1038/nm0295-138

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