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Apoptosis in HIV infection

It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)

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References

  1. Terai, C., Kornbluth, R.S., Pauza, C.D., Richman, D.D. & Carson, D.A. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV–1. J. clin. Invest. 87, 1710–1715 (1991).

    Article  CAS  Google Scholar 

  2. Laurent-Crawford, A.G., Krust, B. & Muller, S. The cytopathic effect of HIV is associated with apoptosis. Virology 185, 829–839 (1991).

    Article  CAS  Google Scholar 

  3. Ameisen, J.C. & Capron, A. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol. Today 12, 102–105 (1991).

    Article  CAS  Google Scholar 

  4. Gougeon, M.L. et al. Mise en evidence d'un processus d'engagment vers la mort cellulaire par apoptose dans les lymphocytes de patients infectes par le VIH. C. R. Acad. Sci. Paris Ser II Sci. Vie 312, 529–537 (1991).

    CAS  Google Scholar 

  5. Meyaard, L. et al. Programmed death of T cells in HIV-1 infection. Science 257, 217–219 (1992).

    Article  CAS  Google Scholar 

  6. Banda, N.K. et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 176, 1099–1106 (1992).

    Article  CAS  Google Scholar 

  7. Finkel, T.H. et al. Apoptosis occurs predominant-lyon bystander cells and not in productively infected cells of HIV-and SIV-infected Lymph nodes. Nature Med. 1, 129–134 (1995)

    Article  CAS  Google Scholar 

  8. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355–359 (1993).

    CAS  Google Scholar 

  9. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359–362 (1993).

    Article  CAS  Google Scholar 

  10. Meyaard, L. et al. J. clin. Invest. 93, 982 (1994).

    Article  CAS  Google Scholar 

  11. Pantaleo, G. et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol. Rev. 140, 105–130 (1994).

    Article  CAS  Google Scholar 

  12. Cohen, J.J. et al. Ann. Rev. Immunol. (1992).

  13. Lenardo, M.J. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353, 858–861 (1991).

    Article  CAS  Google Scholar 

  14. Wesselborg, S., Janssen, O. & Kabelitz, D. Induction of activation–driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150, 4338–4345 (1993).

    CAS  PubMed  Google Scholar 

  15. Ascher, M.S. & Sheppard, H.W. AIDS as immune system activation. II. The Panergic Imnesia Hypothesis. J. AIDS 3, 177–191 (1990).

    CAS  Google Scholar 

  16. Pantaleo, G. & Fauci, A.S. Tracking HIV during disease progression. Curr. Opin. Immunol. 6, 600–604 (1994).

    Article  CAS  Google Scholar 

Download references

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Pantaleo, G., Fauci, A. Apoptosis in HIV infection. Nat Med 1, 118–120 (1995). https://doi.org/10.1038/nm0295-118

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