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Integrating insights from studies of individual nutrients, foods and diseases with studies of holistic dietary patterns and healthy aging can offer a comprehensive strategy for understanding and promoting public health.
We show that hematopoiesis in a mouse model of VEXAS syndrome is subverted by inflammation-resilient, senescent-like mutant HSPCs, which have dysfunctional differentiation and undermine hematopoiesis through their proinflammatory progeny. This disease mechanism explains clonal dominance and bone marrow failure (BMF) in patients with VEXAS syndrome and could have translational implications.
A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered gut microbiome.
A noninferiority trial done in rural villages in Pakistan showed that cognitive-behavioral therapy delivered by lived-experience peers using a digital technology platform was noninferior to community health workers in sustaining remission of perinatal depression over the course of 6 months.
The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.
Results from the randomized ProfiLER-02 trial, which compared two gene panels in guiding molecular-based treatment in patients with solid tumors, show that a broader gene panel led to more molecular-based recommended therapies compared to a more limited gene panel.
In a large trial involving 180 classes in different contexts in China, interactions with a chatbot provided to parents increased uptake and appointments for human papillomavirus vaccination, with stronger increases in rural areas.
Analyses of single-cell transcriptomic data from patients with VEXAS syndrome combined with xenotransplantation experiments in a mouse model of the disease provide insights on the mechanisms of clonal dominance of mutated cells leading to bone marrow failure
A panel of nine LLMs was exposed to simulated clinical cases with switched sociodemographic features exploring ethnic, social, sexual orientation and gender dimensions and showed differences in recommendations for patient treatment, referral and follow-up based only on these features.
National implementation of a computed tomographic angiography and AI-diagnostic tool, CT-derived fractional flow reserve (FFR-CT), did not provide significant benefits in reducing mortality but led to fewer invasive coronary angiograms and downstream cardiac tests.
In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.
In this phase 1 trial, patients with heavily pretreated and refractory CD30+ lymphoma were safely treated with donor-cord-blood-derived NK cells that were precomplexed with the anti-CD30 and anti-CD16A bispecific antibody AFM13, showing encouraging preliminary clinical response rates.
In a quasi-experimental, pre–post-implementation study involving 51,760 hospitalizations, an electronic health record-based risk prediction model informed clinicians of patients needing consultation on opioid use disorder and decreased readmissions to the hospital, without increasing referral rates and with promising cost-effectiveness results.
A randomized crossover trial showed that transition to a Western diet resulted in pro-inflammatory changes, whereas transition to an African heritage diet rich in fruits and vegetables, legumes and fermented products led to opposite effects.
Genome-wide association analyses of 42 female reproductive disorders identify 195 associations between genetic variants and reproductive health traits, including previously unidentified risk factors for ovarian cysts and uterine fibroids. We characterize the genetic architecture of studied traits and highlight the potential of a polygenic risk score to enhance risk prediction for intrahepatic cholestasis of pregnancy.
The TAILORED-AF trial used artificial intelligence (AI)-guided mapping to enhance catheter ablation in persistent atrial fibrillation and demonstrated reductions in recurrent atrial fibrillation, but the net clinical benefit remains unclear.
