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It is not just a woman’s problem; treating male partners of women with bacterial vaginosis resulted in significantly lower recurrence rates than treating women only.
Exploratory post hoc analysis of molecular residual disease from the ADAURA trial of adjuvant osimertinib in patients with resected EGFR-mutated stage IB–IIIA non-small-cell lung cancer shows that molecular residual disease detection predicts disease recurrence with long-term adjuvant osimertinib treatment.
Geospatial modeling analyses in Malawi identified HIV treatment deserts, clusters of communities with either very low or high levels of access to HIV treatment services, reflecting extreme geographic misalignment of healthcare resource allocation.
Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM2.5 and black carbon pollution over a period of 5 years.
Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.
H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 vaccination.
In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.
Understanding the human exposome is now possible with clinics, communities and cities acting as real-world testbeds to understand what drives human healthspan, resilience and flourishing.
As part of Mobile WACh NEO, a parallel, unblinded, randomized controlled trial at six health facilities across Kenya, a text messaging communication intervention had no effect on neonatal mortality compared to standard of care.
The Lancet Global Health Commission on medical oxygen security highlights catastrophic failures of governments and other stakeholders to provide equitable access to this lifesaving resource, and sets out recommendations to close the gap.