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In an observational cohort of pregnant women in Israel, the BNT162b2 COVID-19 vaccine was found to have effectiveness similar to that seen in the general population.

A phase 1 trial involving controlled infection showed that CIS43LS was safe to use and effectively prevented infection with the malaria parasite.

Mandates and incentives are being considered to increase uptake of vaccines against COVID-19, but payment for vaccination may be the fairest approach.

The inclusion of polygenic risk scores does not improve the performance of standard-of-care predictive models of disease outcomes in patients with psychosis.

Cytokine blockade can improve the survival rate of patients with COVID-19 who are at risk of respiratory failure, but timing and patient selection are key.

A new study from the WHO African Region identifies features of countries that predict timing of the first case and the per capita mortality rate for the first and second waves of the COVID-19 epidemics.

The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1α/β inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor.

The first preliminary evidence that in vivo gene editing in a clinical setting is feasible with no early signs of severe adverse events comes from an ongoing clinical trial to treat transthyretin amyloidosis, a fatal monogenetic disease.

Early clinical data for the bispecific antibody teclistamab are encouraging, and further studies are planned.

Microglial activation and tau accumulation propagate together in patients with Alzheimer’s disease, suggesting an interaction that determines disease progression.

A study shows how fermented foods such as keffir and kimchi enhance microbiome diversity and reduce markers of inflammation.

A new approach based on machine-learning integration of 2.1 billion lab measurements of 92 different lab tests from 2.8 million adults, over a span of 18 years, produces models that can stratify one’s risk of having a future abnormal lab test level and subsequent emerging disease.

The association between certain mitochondrial DNA variants and increased risk of late-onset diseases in humans could be explained by a direct role of mitochondrial DNA in the regulation of cellular proteostasis.

Lack of rigor in approving aducanumab for Alzheimer’s disease may lead to serious harm.

Approval of aducanumab will herald a new era in Alzheimer’s disease care and research.

A new cluster randomized controlled trial conducted in 13 American states demonstrates that a social media advertising campaign using videos of healthcare professionals to encourage users to stay at home over the holiday season was effective in reducing travel and subsequent spread of COVID-19.