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Volume 7 Issue 4, April 2006

Immune cells respond to a variety of external cues, suggesting specialized microenvironments, depicted by the various doorways, can profoundly influence their function. This month we present a series of commissioned review articles that focus on unique anatomical niches that are key to immune cell development and function. These reviews and additional internet-only content are available free online (www.nature.com.ni/focus/niches/index.html) during April 2006. Artwork by Lewis Long.

Volume 7 Issue 4

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Editorial

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Overview

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Review Article

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Research Highlights

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Essay

  • The stimulation of antigen-specific CD8+ T cells by the presentation of antigen acquired from outside the cell was the startling conclusion of Michael Bevan's work done more than 30 years ago.

    • Michael J Bevan
    Essay
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News & Views

  • Ikaros regulatory proteins are essential for proper lymphoid cell development. Several new functions for Ikaros have been defined by surrogate marker expression in early hematopoietic progenitor populations.

    • Stephen T Smale
    • Kenneth Dorshkind
    News & Views

  • Deubiquitinating enzymes remove polyubiquitin chains from and alter the fate of specific target proteins. The CYLD deubiquitinating enzyme regulates proximal T cell receptor signaling in thymocytes by selectively binding to and deubiquitinating the active form of the kinase Lck.

    • Neil Lineberry
    • C Garrison Fathman
    News & Views

  • The adaptor protein MyD88 is involved in interleukin 1 receptor and Toll-like receptor signaling. Unexpectedly, new evidence shows that MyD88 also participates in interferon-γ-induced cellular responses.

    • Jiahuai Han
    News & Views
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Article

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Erratum

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Focus

  • Five especially commissioned articles that discuss how immune cells communicate in selected tissue microenvironments.

    Focus
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