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Volume 7 Issue 12, December 2006

Like a jigsaw puzzle, in which individual pieces form a larger, more complex image, the innate immune system is composed of many individual elements that together form an intricate defense network. The now well documented Toll-like receptors make up only one part of this system. Here we focus on four non-Toll-like innate immune protein families in a series of specially commissioned review articles available free online (www.nature.com/ni/focus/innateproteins) during December 2006. Artwork by Lewis Long.

Volume 7 Issue 12

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Editorial

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Overview

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Review Article

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Research Highlights

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Essay

  • Emil R. Unanue recounts his seminal work 25 years ago demonstrating that antigens are phagocytosed and processed by antigen-presenting cells and that class II major histocompatibility complex molecules are peptide-binding proteins.

    • Emil R Unanue
    Essay
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Meeting Report

  • The recent meeting on “Immune Correlates of Protection from HIV Infection and Disease” examined new data from a variety of preclinical and clinical settings. These new insights may facilitate vaccine design and clinical evaluation.

    • Jonathan L Heeney
    • Stanley A Plotkin
    Meeting Report
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News & Views

  • Lymphocyte development must be tightly regulated in utero to prevent rejection. New work shows that the zinc finger protein Zfp608 negatively regulates the expression of recombination-activating genes 1 and 2 and may suppress fetal T cell development.

    • Andrea C Carpenter
    • Craig H Bassing
    News & Views

  • New data show that integrin signaling by the Syk tyrosine kinase requires adaptors, such as DAP12, that have immunoreceptor tyrosine-based activation motifs.

    • Mark L Kahn
    • Gary A Koretzky
    News & Views

  • Fever is a beneficial systemic response to infection. Such a thermal increase triggers enhanced lymph node recruitment of lymphocytes by augmenting high endothelial venule expression of the homing molecules ICAM-1 and CCL21.

    • Shannon K Bromley
    • Andrew D Luster
    News & Views
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Article

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Erratum

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Focus

  • A comprehensive overview and four review articles discuss the functions of plant and animal innate immune system receptors in the context of pathogen recognition and other immune functions.

    Focus
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