Fever is a beneficial systemic response to infection. Such a thermal increase triggers enhanced lymph node recruitment of lymphocytes by augmenting high endothelial venule expression of the homing molecules ICAM-1 and CCL21.
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Bromley, S., Luster, A. Turning up the heat on HEVs. Nat Immunol 7, 1288–1290 (2006). https://doi.org/10.1038/ni1206-1288
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DOI: https://doi.org/10.1038/ni1206-1288
