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Fetal thymocyte development: putting a zinc finger on it?

Nature Immunology volume 7, pages 1285–1286 (2006)Cite this article

Lymphocyte development must be tightly regulated in utero to prevent rejection. New work shows that the zinc finger protein Zfp608 negatively regulates the expression of recombination-activating genes 1 and 2 and may suppress fetal T cell development.

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Figure 1: Potential transcriptional targets of Zfp608 in developing thymocytes.

Kim Caesar

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Authors and Affiliations

  1. Immunology Graduate Group and the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania

    Andrea C Carpenter & Craig H Bassing

Authors
  1. Andrea C Carpenter
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  2. Craig H Bassing
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Carpenter, A., Bassing, C. Fetal thymocyte development: putting a zinc finger on it?. Nat Immunol 7, 1285–1286 (2006). https://doi.org/10.1038/ni1206-1285

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  • DOI: https://doi.org/10.1038/ni1206-1285

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