Volume 6 Issue 3, March 2005

Volume 6 Issue 3

Airborne pollution from motor vehicles and industries is a serious threat to human health. Starting from this month and throughout 2005, Nature Immunology examines the contribution of the environment and our modern lifestyle to the increasing prevalence of allergy. In this issue, Saxon and Diaz-Sanchez (p.223) discuss the potential effects of pollution. Artwork by Lewis Long.



  • Commentary |

    How does air pollution affect asthma and allergic rhinitis? Particulate and gaseous pollution drive proallergic inflammation through the generation of oxidative stress, which is regulated by individual genetic susceptibility.

    • Andrew Saxon
    •  & David Diaz-Sanchez

News and Views

  • News & Views |

    Resting dendritic cells can induce T cell tolerance. This process requires engagement of the costimulatory molecules PD-1 and CTLA-4 on T cells.

    • Abul K Abbas
    •  & Arlene H Sharpe
  • News & Views |

    The long-awaited structure of CD28 provides new understanding of its function and opens new avenues for probing this important costimulatory molecule.

    • Peter S Linsley
  • News & Views |

    A new study uses experimental infection of naive macaques with simian immunodeficiency virus containing known cytotoxic T lymphocyte escape mutations to examine the host and viral forces governing reversion or persistence of escape during transmission between hosts.

    • Mina John
    •  & Simon Mallal
  • News & Views |

    Self-renewal of hematopoietic stem cells allows life-long production of blood cells. Notch signaling is critically involved in this process by maintaining a pool of self-renewing hematopoietic stem cells.

    • Sten Eirik W Jacobsen