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Volume 6 Issue 4, April 2005

The 'yin-yang' icon is a symbol of balance and harmony between two opposing forces. These forces are pervasive in our immune system, where the balance between regulatory T cells and reactive cells is important in maintaining homeostasis. This month we focus on the biology and function of regulatory T cells with a series of specially commissioned articles. The content and additional features are free online (www.nature.com/ni/focus/regulatory_tcells) during April 2005. Cover by Lewis Long.

Volume 6 Issue 4

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Editorial

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Perspective

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Review Article

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Research Highlights

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News & Views

  • Double-positive thymocytes are selected into the CD4 or CD8 lineage on the basis of their T cell receptor specificity. The transcription factor cKrox has been identified as being both required and sufficient to direct thymocytes undergoing positive selection to the CD4 lineage.

    • Rose Zamoyska
    News & Views

  • Different peptide antigens induce T cell repertoires of very different diversity. An analysis of the effect on T cell receptor usage of re-engineering peptide features indicates that a lack of prominent side chains presented for recognition limits the T cell repertoire.

    • E Yvonne Jones
    News & Views

  • The MAP kinase p38 is normally regulated by the MAPKKK-MAPKK pathway in mammalian cells. However, analysis of T cell signaling shows an alternative pathway for p38 activation exists.

    • Christopher E Rudd
    News & Views
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Article

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Corrigendum

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Focus

  • Four review articles and a perspective examine the biology and function of regulatory T cells.

    Focus
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