Volume 18 Issue 10, October 2017

Volume 18 Issue 10

The process by which self-reactive CD4+ T cells infiltrate the central nervous system (CNS) and trigger neuroinflammation is not fully understood. Lazarevic and colleagues (p 1117; News and Views by Brown & Russi, p 1063) show that NKp46+ innate lymphoid cells dependent on the transcription factor T-bet are critical mediators in facilitating the entry of autoreactive CD4+ cells of the TH17 subset of helper T cells into the CNS, which leads to autoimmunity. The original confocal image by Brandon Kwong shows the invasion of CD4+ T cells (red) and other immune cells (nuclei stained with the DNA-binding dye DAPI; white) into a spinal cord section during CNS autoimmune disease. Artwork by Lewis Long.

News and Views

  • News & Views |

    A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.

    • Thomas Korn
  • News & Views |

    Interferon-λ (IFN-λ) curbs neutrophil-mediated intestinal inflammation by diminishing the production of reactive oxygen species and subsequent oxidative stress. This regulatory process is unique to IFN-λ and is independent of interferon-induced transcription and translation programs.

    • Emily A Hemann
    • , Johannes Schwerk
    •  & Ram Savan
  • News & Views |

    T-bet+NKp46+ subsets of group 1 and group 3 innate lymphoid cells within the meninges initiate neuroinflammation in central nervous system (CNS)-demyelinating disease by regulating both the stability of pathogenic T-bet+ T cells and their access to the CNS.

    • Melissa A Brown
    •  & Abigail E Russi
  • News & Views |

    Caveolin-1 has a critical role in orchestrating the membrane organization of B cells. In its absence, signaling via the B cell antigen receptor and B cell tolerance are impaired, which results in autoimmunity.

    • Julie Zikherman
    •  & Clifford A Lowell

Research Highlights





  • Resource |

    Specialized populations of regulatory T cells inhabit tissues and maintain homeostasis, and assist with repair functions there. Feuerer and colleagues identify a genome-wide DNA-methylation landscape to define this specialized subset of cells.

    • Michael Delacher
    • , Charles D Imbusch
    • , Dieter Weichenhan
    • , Achim Breiling
    • , Agnes Hotz-Wagenblatt
    • , Ulrike Träger
    • , Ann-Cathrin Hofer
    • , Danny Kägebein
    • , Qi Wang
    • , Felix Frauhammer
    • , Jan-Philipp Mallm
    • , Katharina Bauer
    • , Carl Herrmann
    • , Philipp A Lang
    • , Benedikt Brors
    • , Christoph Plass
    •  & Markus Feuerer