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B cell autoimmunity at the extremes

Nature Immunology volume 18, pages 1065–1066 (2017)Cite this article

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Caveolin-1 has a critical role in orchestrating the membrane organization of B cells. In its absence, signaling via the B cell antigen receptor and B cell tolerance are impaired, which results in autoimmunity.

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Figure 1: Model for the development of B cell autoimmunity at the extremes of BCR signal strength.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Division of Rheumatology, the Rosalind Russell and Ephraim P. Engleman Arthritis Research Center and the Department of Medicine, University of California San Francisco, San Francisco, California, USA

    Julie Zikherman

  2. Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA

    Clifford A Lowell

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  1. Julie Zikherman
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  2. Clifford A Lowell
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Correspondence to Clifford A Lowell.

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Zikherman, J., Lowell, C. B cell autoimmunity at the extremes. Nat Immunol 18, 1065–1066 (2017). https://doi.org/10.1038/ni.3840

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