Volume 15 Issue 1, January 2014

Volume 15 Issue 1

The sensing of nucleic acids is pivotal for detecting viral infections. Reinecker and colleagues (p 63) show that the microtubule-associated protein GEF-H1 is activated after the intracellular detection of nucleic acids and is required for antiviral defense against RNA viruses. The original image, generated by Hans-Christian Reinecker and Hao-Sen Chiang, shows GEF-H1 (green) and the microtubule network (red); yellow indicates colocalization of GEF-H1 and a-tubulin.Artwork by Lewis Long.

Obituaries

Commentary

  • Commentary |

    To overcome the limitations of seasonal influenza virus vaccines and enhance our pandemic preparedness, influenza virus vaccines that provide universal and long-lasting protection are needed.

    • Florian Krammer
    •  & Peter Palese

News and Views

  • News & Views |

    Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.

    • Zhigang Tian
  • News & Views |

    Plasmacytoid dendritic cells express the microRNA miR-126, which controls their survival and effector functions via the receptor VEGFR2.

    • Marina Cella
    •  & Giorgio Trinchieri
  • News & Views |

    Innate-like T cells are dependent on triggering via the T cell antigen receptor (TCR) for development but subsequently actively alter their TCR responsiveness to allow an innate mode of activation that no longer requires TCR signaling.

    • Tom Cupedo
    •  & Janneke N Samsom

Research Highlights

Review

  • Review Article |

    The transcription factor NF-κB is required for T cell effector function. Gerondakis and colleagues discuss the role of NF-κB in T cell development.

    • Steve Gerondakis
    • , Thomas S Fulford
    • , Nicole L Messina
    •  & Raelene J Grumont

Articles

  • Article |

    The identity of the thymus-seeding progenitor cells has been a matter of debate. Cumano and colleagues report that early and late embryonic progenitor cells differ in their T cell–B cell lineage potential and capacity for population expansion and differentiation.

    • Cyrille Ramond
    • , Claire Berthault
    • , Odile Burlen-Defranoux
    • , Ana Pereira de Sousa
    • , Delphine Guy-Grand
    • , Paulo Vieira
    • , Pablo Pereira
    •  & Ana Cumano
  • Article |

    Paired immunoglobulin-like receptors (PIRs) recognize β2-microglobulin. Munitz and colleagues show that PIR-A and PIR-B have opposing roles in eosinophil development in response to interleukin 5 in the bone marrow.

    • Netali Ben Baruch-Morgenstern
    • , Dana Shik
    • , Itay Moshkovits
    • , Michal Itan
    • , Danielle Karo-Atar
    • , Carine Bouffi
    • , Patricia C Fulkerson
    • , Diana Rashkovan
    • , Steffen Jung
    • , Marc E Rothenberg
    •  & Ariel Munitz
  • Article |

    Weninger and colleagues show that perivascular macrophages are critical for neutrophil migration into skin infected with Staphylococcus aureus and that the pathogen uses hemolysin-dependent killing of these cells as an immune evasion strategy.

    • Arby Abtin
    • , Rohit Jain
    • , Andrew J Mitchell
    • , Ben Roediger
    • , Anthony J Brzoska
    • , Shweta Tikoo
    • , Qiang Cheng
    • , Lai Guan Ng
    • , Lois L Cavanagh
    • , Ulrich H von Andrian
    • , Michael J Hickey
    • , Neville Firth
    •  & Wolfgang Weninger
  • Article |

    Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and function of these cells are regulated by the microRNA miR-126.

    • Judith Agudo
    • , Albert Ruzo
    • , Navpreet Tung
    • , Hélène Salmon
    • , Marylène Leboeuf
    • , Daigo Hashimoto
    • , Christian Becker
    • , Lee-Ann Garrett-Sinha
    • , Alessia Baccarini
    • , Miriam Merad
    •  & Brian D Brown
  • Article |

    RIG-I–like receptors are important inducers of innate immunity. Reinecker and colleagues find that activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1 is essential for sensing of foreign RNA by these receptors.

    • Hao-Sen Chiang
    • , Yun Zhao
    • , Joo-Hye Song
    • , Song Liu
    • , Ninghai Wang
    • , Cox Terhorst
    • , Arlene H Sharpe
    • , Megha Basavappa
    • , Kate L Jeffrey
    •  & Hans-Christian Reinecker
  • Article |

    Polymorphisms near genes encoding members of the IFN-λ family are associated with susceptibility or resistance to hepatitis C virus. Savan and colleagues show that differences in the stability of transcripts of those genes underlie the mechanism of resistance to that virus.

    • Adelle P McFarland
    • , Stacy M Horner
    • , Abigail Jarret
    • , Rochelle C Joslyn
    • , Eckart Bindewald
    • , Bruce A Shapiro
    • , Don A Delker
    • , Curt H Hagedorn
    • , Mary Carrington
    • , Michael Gale Jr
    •  & Ram Savan
  • Article |

    T cell hyporesponsiveness is generally framed in terms of tolerance induction. Hayday and colleagues show that attenuating TCR responsiveness is also critical for the development of innate-like T cells that mediate the surveillance of dysregulated tissues.

    • Melanie Wencker
    • , Gleb Turchinovich
    • , Rafael Di Marco Barros
    • , Livija Deban
    • , Anett Jandke
    • , Andrew Cope
    •  & Adrian C Hayday
  • Article |

    Lymphocyte function is regulated by phosphatidylinositol-dependent pathways. Uzel and colleagues identify a cohort of immunodeficient patients with hyperactive phosphatidylinositol-3-OH kinase activity due to mutant p110δ subunits, which results in enhanced senescence of cells of the immune system.

    • Carrie L Lucas
    • , Hye Sun Kuehn
    • , Fang Zhao
    • , Julie E Niemela
    • , Elissa K Deenick
    • , Umaimainthan Palendira
    • , Danielle T Avery
    • , Leen Moens
    • , Jennifer L Cannons
    • , Matthew Biancalana
    • , Jennifer Stoddard
    • , Weiming Ouyang
    • , David M Frucht
    • , V Koneti Rao
    • , T Prescott Atkinson
    • , Anahita Agharahimi
    • , Ashleigh A Hussey
    • , Les R Folio
    • , Kenneth N Olivier
    • , Thomas A Fleisher
    • , Stefania Pittaluga
    • , Steven M Holland
    • , Jeffrey I Cohen
    • , Joao B Oliveira
    • , Stuart G Tangye
    • , Pamela L Schwartzberg
    • , Michael J Lenardo
    •  & Gulbu Uzel

Resource

Addendum

Addendum

Corrigenda

Erratum