Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.
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References
Suppiah, V. et al. Nat. Genet. 41, 1100–1104 (2009).
Tanaka, Y. et al. Nat. Genet. 41, 1105–1109 (2009).
Ge, D. et al. Nature 461, 399–401 (2009).
Thomas, D.L. et al. Nature 461, 798–801 (2009).
McFarland, A. et al. Nat. Immunol. 15, 72–79 (2014).
Thomas, D.L. Nat. Med. 19, 850–858 (2013).
Rehermann, B. Nat. Med. 19, 859–868 (2013).
Lanford, R.E. et al. Science 327, 198–201 (2010).
Janssen, H.L. et al. N. Engl. J. Med. 368, 1685–1694 (2013).
Knapp, S. et al. Hepatology 51, 1168–1175 (2010).
Rehermann, B. & Nascimbeni, M. Nat. Rev. Immunol. 5, 215–229 (2005).
Arzumanyan, A., Reis, H.M. & Feitelson, M.A. Nat. Rev. Cancer 13, 123–135 (2013).
Holder, K.A., Stapleton, S.N., Gallant, M.E., Russell, R.S. & Grant, M.D. J. Immunol. 191, 3308–3318 (2013).
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Tian, Z. Outflanking HCV. Nat Immunol 15, 6–8 (2014). https://doi.org/10.1038/ni.2783
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DOI: https://doi.org/10.1038/ni.2783
