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Volume 1 Issue 2, August 2000

In the small intestine, at the bottom of the villi, lie the crypts. Ayabe et al. on page 113 report that Paneth cells, brown in the tissue slice and purplish in the artist's rendition, sense the presence of bacteria and secrete defensins to protect the surrounding tissue (see also page 99 for the News & Views by T. Ganz). Photo by Edith Porter and Tomas Ganz.Art by Lewis Long.

Volume 1 Issue 2

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Editorial

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Correspondence

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Commentary

  • Historical Insight: The immunologic relationship between the fetus and its parents has fascinated investigators for generations. Early experiments by Ehrlich, as recounted here by Arthur Silverstein, clarified some crucial issues and paved the way for studies that are still ongoing today.

    • Arthur M. Silverstein
    Commentary
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News & Views

  • NK cells become cytotoxic upon receiving a signal through their activation receptors. The orphan proteins H-60 and Rae1 have now been identified as ligands for the mouse NKG2D activation receptor. Remarkably they are inducible and may be blocked by a viral protein.

    • Wayne M. Yokoyama
    News & Views

  • Protection of the small intestine from harmful bacteria is a never-ending job. Paneth cells of the intestinal crypts function as prime producers of defensins in response to the microbial onslaught of the gut.

    • Tomas Ganz
    News & Views

  • Tumor vaccines comprised of the chaperone gp96 can instigate specific immunity to tumor peptides. A receptor on macrophages for the uptake of peptide-loaded gp96 has been identified as CD91, the α2-macroglobulin receptor.

    • Hansjörg Schild
    • Hans-Georg Rammensee
    News & Views

  • Much vaccine research is directed toward the generation of more effective vaccines. By combining DNA vaccines with the innate immune system, a flu vaccine was designed that required only a single immunization.

    • Douglas T. Fearon
    News & Views
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Round-up

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