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Global immunization of children is an elusive goal of public health officials world-wide. Extraordinary recent funding and organizational initiatives as described by Gustav Nossal have ignited renewed optimism that the stage is finally set to bring this acheivement within our grasp.
Marginal zone B cells may steal the limelight as the roles of Pyk-2 and BLyS begin to be elucidated. Pyk-2 deficiency leads to their loss whereas signaling via the BLyS receptor may augment their function.
Memory is generated with most T cell responses. The effectiveness and power of CD8+ memory T cells may be due to their quicker responses and broader capabilities.
The enzyme cPLA2 plays a pivotal role in adult respiratory distress syndrome (ARDS). Specific blocking of cPLA2 may present a useful therapeutic target for treating ARDS.
Without Brca1, T cells are lacking in numbers and maturity, but surprisingly not because of a lack of repair of rearranged TCR genes. The defects involve more than one p53-dependent mechanism.
STATs are critical in immune responses to type 1 IFNs. The human and mouse pathways differ, partly due to differences in STAT2, but unpredicted responses after viral infections raise new questions.
