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Structural studies of CD1d presentation of α-galactosylceramide have shown that the lipid component fits snugly in the cleft, whereas the galactosyl head group protrudes upward, with key contact points between CD1d and the antigen conserved between mouse and human structures.
The US has entered a new period of fiscal restraint. What does this mean for basic research? Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, discusses the way forward for research scientists in the US.
After leaving lymphoid tissues, do T cells receive additional signals for survival and differentiation at effector sites? A unique cell population in the intestinal lamina propria may provide such a signal via the costimulatory molecule CD70.
Tumors that develop in immunocompetent hosts show reduced immunogenicity because of selective pressure to escape destruction by immune cells. Type I interferons are involved in shaping this evasive response but, unexpectedly, tumor cells are not the main targets of these interferons.