Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.
Naive CD8+ T cells can be activated via dendritic cell 'cross-priming' of antigens obtained exogenously. Dendritic cells cannot cross-prime, however, after systemic activation in vivo, potentially contributing to immunosuppression associated with severe infections.
'Forward' genetic approaches for elucidating function can lead to unexpected findings. A single missense mutation is found to disrupt both antigen presentation and nucleic acid Toll-like receptor signaling, two processes involving endocytic pathways.
Historical accounts of important experiments in Immunology provide insight and continuity to present areas of research. Jacques F.A.P. Miller inaugurates the Essay format with his seminal work on the thymus.
CD8+ T cell recognition of peptides presented by major histocompatibility complex class I molecules is essential for effective antiviral and antitumor immune responses. How the repertoire of peptides is selected, shaped and presented is becoming increasingly clear.
How regulatory T cells dampen T cell responses in vivo remains unclear. Direct visualization of regulatory T cell activity in an autoimmune setting provides exciting new insights into regulatory T cell–mediated suppression.